Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

doi:10.1021/jm3017656

Title: Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

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Authors:

Liedtke, Andy J. ^[1]; Adeniji, Adegoke O. ^[2]; Chen, Mo ^[2]; Byrns, Michael C. ^[2]; Jin, Yi ^[2]; Christianson, David W. ^[3]; Marnett, Lawrence J. ^[1]; Penning, Trevor M. ^[2]

Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States
Department of Pharmacology and Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, 1315 BRB II/III, 420 Curie Boulevard, Philadelphia, Pennsylvania 19104-6061, United States
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

Publication Date:: 2013-03-07

Sponsoring Org.:: USDOE

OSTI Identifier:: 1123359

Resource Type:: Published Article

Journal Name:: Journal of Medicinal Chemistry

Additional Journal Information:: Journal Name: Journal of Medicinal Chemistry Journal Volume: 56 Journal Issue: 6; Journal ID: ISSN 0022-2623

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

Citation Formats


                    Liedtke, Andy J., Adeniji, Adegoke O., Chen, Mo, Byrns, Michael C., Jin, Yi, Christianson, David W., Marnett, Lawrence J., and Penning, Trevor M. Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer.  United States: N. p., 2013. 
        Web.  doi:10.1021/jm3017656.

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                    Liedtke, Andy J., Adeniji, Adegoke O., Chen, Mo, Byrns, Michael C., Jin, Yi, Christianson, David W., Marnett, Lawrence J., & Penning, Trevor M. Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer.  United States.  doi:10.1021/jm3017656.

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                    Liedtke, Andy J., Adeniji, Adegoke O., Chen, Mo, Byrns, Michael C., Jin, Yi, Christianson, David W., Marnett, Lawrence J., and Penning, Trevor M. Thu .  
        "Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer".  United States.  doi:10.1021/jm3017656.

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@article{osti_1123359,

  title        = {Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer},

  author       = {Liedtke, Andy J. and Adeniji, Adegoke O. and Chen, Mo and Byrns, Michael C. and Jin, Yi and Christianson, David W. and Marnett, Lawrence J. and Penning, Trevor M.},

  abstractNote = {},

  doi          = {10.1021/jm3017656},

  journal      = {Journal of Medicinal Chemistry},

  number       = 6,

  volume       = 56,

  place        = {United States},

  year         = {2013},

  month        = {3}

}

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DOI: 10.1021/jm3017656

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Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17 beta-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

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