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Title: Bubble diagnostics

Abstract

The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.

Inventors:
 [1];  [2];  [3];  [4]
  1. (Livermore, CA)
  2. (Walnut Creek, CA)
  3. (Danville, CA)
  4. (Berkeley, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
875130
Patent Number(s):
6538739
Assignee:
The Regents of the University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
bubble; diagnostics; intended; means; diagnosing; presence; gas; incorporating; information; feedback; opto-acoustic; thrombolysis; pulsed; laser; radiation; ultrasonic; frequencies; delivered; intraluminally; optical; fiber; directed; thrombus; otherwise; occluded; vessel; dissolution; occlusion; mediated; action; propagating; pressure; shock; waves; vapor; fluid; surrounding; form; result; irradiation; directly; disrupt; producing; wave; desirable; detect; formation; follow; lifetime; knowledge; yields; critical; maximum; size; density; absorbed; properties; absorbing; material; alter; conditions; optical fiber; laser radiation; pulsed laser; pressure wave; gas bubble; /356/

Citation Formats

Visuri, Steven R., Mammini, Beth M., Da Silva, Luiz B., and Celliers, Peter M. Bubble diagnostics. United States: N. p., 2003. Web.
Visuri, Steven R., Mammini, Beth M., Da Silva, Luiz B., & Celliers, Peter M. Bubble diagnostics. United States.
Visuri, Steven R., Mammini, Beth M., Da Silva, Luiz B., and Celliers, Peter M. Wed . "Bubble diagnostics". United States. https://www.osti.gov/servlets/purl/875130.
@article{osti_875130,
title = {Bubble diagnostics},
author = {Visuri, Steven R. and Mammini, Beth M. and Da Silva, Luiz B. and Celliers, Peter M.},
abstractNote = {The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

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