skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method for measuring lead concentrations in blood

Abstract

Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.

Inventors:
 [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
873797
Patent Number(s):
6248592
Assignee:
Regents of University of California (Los Alamos, MX)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; measuring; lead; concentrations; blood; resonant; laser; ablation; analyze; ltoreq; equivalent; mass; samples; content; typical; finger; prick; example; yields; 10; solid; readily; analyzed; sample; placed; lead-free; electrically; conducting; substrate; irradiated; single; focused; beam; simultaneously; vaporizes; atomizes; resonantly; ionizes; analyte; sorted; collected; detected; spectrometer; focused laser; solid sample; mass spectrometer; laser beam; electrically conducting; laser ablation; measuring lead; resonant laser; lead content; conducting substrate; lead concentrations; /436/

Citation Formats

Nogar, Nicholas S. Method for measuring lead concentrations in blood. United States: N. p., 2001. Web.
Nogar, Nicholas S. Method for measuring lead concentrations in blood. United States.
Nogar, Nicholas S. Mon . "Method for measuring lead concentrations in blood". United States. https://www.osti.gov/servlets/purl/873797.
@article{osti_873797,
title = {Method for measuring lead concentrations in blood},
author = {Nogar, Nicholas S},
abstractNote = {Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Laser desorption mass spectrometry of nonvolatiles under shock wave conditions
journal, April 1985


Resonant laser ablation—a novel surface analytic technique
journal, October 1992


Resonant Laser Ablation: Semiquantitative Aspects and Threshold Effects
journal, December 1994


LAMMA 500 principle and technical description of the instrument
journal, January 1981


Chromium detection by laser desorption and resonance ionization mass spectrometry
journal, March 1992


Direct determination of lead in blood by laser-excited flame atomic-fluorescence spectrometry
journal, January 1984


Comparison of Laser and Ion Microprobe Detection Sensitivity for Lead in Biological Microanalysis
journal, February 1985


A high-sensitivity laser microprobe mass analyzer
journal, December 1975


Pulsed laser resonance ionization mass spectrometry for elementally selective detection of lead and bismuth mixtures
journal, September 1988


Need for better tests for lead in blood is urgent
journal, October 1993