Method for measuring lead concentrations in blood
Abstract
Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.
- Inventors:
-
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 873797
- Patent Number(s):
- 6248592
- Assignee:
- Regents of University of California (Los Alamos, MX)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; measuring; lead; concentrations; blood; resonant; laser; ablation; analyze; ltoreq; equivalent; mass; samples; content; typical; finger; prick; example; yields; 10; solid; readily; analyzed; sample; placed; lead-free; electrically; conducting; substrate; irradiated; single; focused; beam; simultaneously; vaporizes; atomizes; resonantly; ionizes; analyte; sorted; collected; detected; spectrometer; focused laser; solid sample; mass spectrometer; laser beam; electrically conducting; laser ablation; measuring lead; resonant laser; lead content; conducting substrate; lead concentrations; /436/
Citation Formats
Nogar, Nicholas S. Method for measuring lead concentrations in blood. United States: N. p., 2001.
Web.
Nogar, Nicholas S. Method for measuring lead concentrations in blood. United States.
Nogar, Nicholas S. Mon .
"Method for measuring lead concentrations in blood". United States. https://www.osti.gov/servlets/purl/873797.
@article{osti_873797,
title = {Method for measuring lead concentrations in blood},
author = {Nogar, Nicholas S},
abstractNote = {Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
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