Micromechanical calorimetric sensor
Abstract
A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0more »
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 873126
- Patent Number(s):
- 6096559
- Assignee:
- Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-96OR22464
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- micromechanical; calorimetric; sensor; calorimeter; apparatus; developed; utilizing; microcantilevered; spring; elements; detecting; thermal; changes; sample; containing; biomolecules; undergo; chemical; biochemical; reactions; element; bimaterial; layer; chemicals; coated; region; surface; microcantilever; generate; differential; stress; reaction; analyte; due; heat; placed; creates; mechanical; bending; mass; allow; detection; measuring; transfers; associated; near; material; inert; composition; surfaces; create; cantilever; deflections; detected; variety; techniques; approximately; 200; 50; wide; thick; sensitivity; range; 01; nanometers; extremely; sensitive; samples; 30; microliters; material layer; detection techniques; extremely sensitive; differential thermal; spring element; sample containing; thermal stress; heat transfer; chemical reaction; sensor apparatus; chemical reactions; thermal mass; microcantilevered spring; thermal changes; biochemical reactions; detecting thermal; /436/422/
Citation Formats
Thundat, Thomas G, and Doktycz, Mitchel J. Micromechanical calorimetric sensor. United States: N. p., 2000.
Web.
Thundat, Thomas G, & Doktycz, Mitchel J. Micromechanical calorimetric sensor. United States.
Thundat, Thomas G, and Doktycz, Mitchel J. Sat .
"Micromechanical calorimetric sensor". United States. https://www.osti.gov/servlets/purl/873126.
@article{osti_873126,
title = {Micromechanical calorimetric sensor},
author = {Thundat, Thomas G and Doktycz, Mitchel J},
abstractNote = {A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}
Works referenced in this record:
Observation of a chemical reaction using a micromechanical sensor
journal, January 1994
- Gimzewski, J. K.; Gerber, Ch.; Meyer, E.
- Chemical Physics Letters, Vol. 217, Issue 5-6, p. 589-594