Method for preparing radionuclide-labeled chelating agent-ligand complexes

Meares, Claude F; Li, Min; DeNardo, Sally J

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Title: Method for preparing radionuclide-labeled chelating agent-ligand complexes

Abstract

Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.

Inventors:

Meares, Claude F ^[1]; Li, Min ^[1]; DeNardo, Sally J ^[2]

Davis, CA
El Macero, CA

Issue Date:: Fri Jan 01 00:00:00 EST 1999

Research Org.:: Univ. of California (United States)

OSTI Identifier:: 872538

Patent Number(s):: 5958374

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A61F2013/51415 - {with pores}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2121/00 - Preparations for use in therapy
A61K2123/00 - Preparations for testing in vivo
A61K51/1093 - {conjugates with carriers being antibodies}

Show less

DOE Contract Number:: FG03-84ER60233

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; preparing; radionuclide-labeled; chelating; agent-ligand; complexes; useful; medical; diagnosis; therapy; prepared; reacting; radionuclide; 90; 111; polyfunctional; agent; form; chelate; electrically; neutral; purifying; anion; exchange; chromatography; purified; targeting; molecule; monoclonal; antibody; complex; monoclonal antibody; anion exchange; chelating agent; radionuclide-labeled chelating; chelating agent-ligand; medical diagnosis; exchange chromatography; agent-ligand complexes; ligand complex; /424/999/

Citation Formats


                    Meares, Claude F, Li, Min, and DeNardo, Sally J. Method for preparing radionuclide-labeled chelating agent-ligand complexes.  United States: N. p., 1999. 
        Web.

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                    Meares, Claude F, Li, Min, & DeNardo, Sally J. Method for preparing radionuclide-labeled chelating agent-ligand complexes.  United States.

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                    Meares, Claude F, Li, Min, and DeNardo, Sally J. Fri .  
        "Method for preparing radionuclide-labeled chelating agent-ligand complexes".  United States.  https://www.osti.gov/servlets/purl/872538.

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@article{osti_872538,

  title        = {Method for preparing radionuclide-labeled chelating agent-ligand complexes},

  author       = {Meares, Claude F and Li, Min and DeNardo, Sally J},

  abstractNote = {Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 1999},

  month        = {Fri Jan 01 00:00:00 EST 1999}

}

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Works referenced in this record:

Synthesis, metal chelate stability studies, and enzyme digestion of a peptide-linked DOTA derivative and its corresponding radiolabeled immunoconjugates
journal, July 1993

Li, Min; Meares, Claude F.
Bioconjugate Chemistry, Vol. 4, Issue 4
https://doi.org/10.1021/bc00022a005

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.
journal, June 1988

Fritzberg, A. R.; Abrams, P. G.; Beaumier, P. L.
Proceedings of the National Academy of Sciences, Vol. 85, Issue 11
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Immunochemical aspects of monoclonal antibodies important for radiopharmaceutical development
journal, January 1986

DeNardo, Sally J.; Peng, Jo-Sen B.; DeNardo, Gerald L.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 13, Issue 4
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A kinetic investigation of the lanthanide DOTA chelates. Stability and rates of formation and of dissociation of a macrocyclic gadolinium(III) polyaza polycarboxylic MRI contrast agent
journal, March 1992

Wang, Xiangyun; Jin, Tianzhu; Comblin, Vinciane
Inorganic Chemistry, Vol. 31, Issue 6
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Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelates
journal, January 1991

Gansow, Otto A.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 18, Issue 4
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The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent
journal, January 1987

Franz, J.; Volkert, W. A.; Barefield, E. K.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 14, Issue 6
https://doi.org/10.1016/0883-2897(87)90027-4

Synthesis of C- and N-functionalised derivatives of 1,4,7-triazacyclononane-1,4,7-triyltriacetic acid (NOTA), 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetrayltetra-acetic acid (DOTA), and diethylenenetriaminepenta-acetic acid (DTPA): bifunctional complexing agents for the derivatisation of antibodies
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Cox, Jonathan P. L.; Craig, Andrew S.; Helps, Ian M.
Journal of the Chemical Society, Perkin Transactions 1, Issue 9
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Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions
journal, October 1984

Meares, Claude F.; McCall, Michael J.; Reardan, Dayton T.
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Thermodynamic and kinetic studies of lanthanide complexes of 1,4,7,10,13-pentaazacyclopentadecane-N,N',N'',N''',N''''-pentaacetic acid and 1,4,7,10,13,16-hexaazacyclooctadecane-N,N',N'',N''',N'''',N'''''-hexaacetic acid
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Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC [phenyl isothiocyanate].
journal, May 1991

Linder, K. E.; Wen, M. D.; Nowotnik, D. P.
Bioconjugate Chemistry, Vol. 2, Issue 3
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The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex
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Similar Records

Title: Method for preparing radionuclide-labeled chelating agent-ligand complexes

Abstract

Citation Formats

Synthesis, metal chelate stability studies, and enzyme digestion of a peptide-linked DOTA derivative and its corresponding radiolabeled immunoconjugates journal, July 1993

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. journal, June 1988

Immunochemical aspects of monoclonal antibodies important for radiopharmaceutical development journal, January 1986

A kinetic investigation of the lanthanide DOTA chelates. Stability and rates of formation and of dissociation of a macrocyclic gadolinium(III) polyaza polycarboxylic MRI contrast agent journal, March 1992

Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelates journal, January 1991

The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent journal, January 1987

Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions journal, October 1984

Thermodynamic and kinetic studies of lanthanide complexes of 1,4,7,10,13-pentaazacyclopentadecane-N,N',N'',N''',N''''-pentaacetic acid and 1,4,7,10,13,16-hexaazacyclooctadecane-N,N',N'',N''',N'''',N'''''-hexaacetic acid journal, March 1991

Kinetics of interaction of metal ions with two tetraazatetraacetate macrocycles journal, September 1982

Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC [phenyl isothiocyanate]. journal, May 1991

The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex journal, August 1988

Copper chelates as probes of biological systems: Stable copper complexes with a macrocyclic bifunctional chelating agent journal, July 1985

[47] A centrifuged-column procedure for the measurement of ligand binding by beef heart F1 book, January 1979

Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies: Radionuclide selection and dose calculations for labeled antibodies journal, September 1984

Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site. journal, August 1992

Tumour targeting with radiolabelled macrocycle–antibody conjugates journal, January 1990

Synthesis, metal chelate stability studies, and enzyme digestion of a peptide-linked DOTA derivative and its corresponding radiolabeled immunoconjugates
journal, July 1993

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.
journal, June 1988

Immunochemical aspects of monoclonal antibodies important for radiopharmaceutical development
journal, January 1986

A kinetic investigation of the lanthanide DOTA chelates. Stability and rates of formation and of dissociation of a macrocyclic gadolinium(III) polyaza polycarboxylic MRI contrast agent
journal, March 1992

Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelates
journal, January 1991

The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent
journal, January 1987

Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions
journal, October 1984

Thermodynamic and kinetic studies of lanthanide complexes of 1,4,7,10,13-pentaazacyclopentadecane-N,N',N'',N''',N''''-pentaacetic acid and 1,4,7,10,13,16-hexaazacyclooctadecane-N,N',N'',N''',N'''',N'''''-hexaacetic acid
journal, March 1991

Kinetics of interaction of metal ions with two tetraazatetraacetate macrocycles
journal, September 1982

Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC [phenyl isothiocyanate].
journal, May 1991

The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex
journal, August 1988

Copper chelates as probes of biological systems: Stable copper complexes with a macrocyclic bifunctional chelating agent
journal, July 1985

[47] A centrifuged-column procedure for the measurement of ligand binding by beef heart F1
book, January 1979

Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies: Radionuclide selection and dose calculations for labeled antibodies
journal, September 1984

Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site.
journal, August 1992

Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990