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Title: Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands

Abstract

Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600190
Patent Number(s):
10,450,336
Application Number:
14/703,253
Assignee:
Triad National Security, LLC (Los Alamos, NM)
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/04/2015
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats

Wilson, Justin, Birnbaum, Eva, John, Kevin, Nortier, Francois, Fassbender, Michael, Radchenko, Valery, and Engle, Jonathan Ward. Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands. United States: N. p., 2019. Web.
Wilson, Justin, Birnbaum, Eva, John, Kevin, Nortier, Francois, Fassbender, Michael, Radchenko, Valery, & Engle, Jonathan Ward. Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands. United States.
Wilson, Justin, Birnbaum, Eva, John, Kevin, Nortier, Francois, Fassbender, Michael, Radchenko, Valery, and Engle, Jonathan Ward. Tue . "Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands". United States. https://www.osti.gov/servlets/purl/1600190.
@article{osti_1600190,
title = {Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands},
author = {Wilson, Justin and Birnbaum, Eva and John, Kevin and Nortier, Francois and Fassbender, Michael and Radchenko, Valery and Engle, Jonathan Ward},
abstractNote = {Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {10}
}

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Works referenced in this record:

Bismuth-213 generator and uses thereof
patent, August 2003