Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands

Title: Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands

Abstract

Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.

Inventors:: Wilson, Justin; Birnbaum, Eva; John, Kevin; Nortier, Francois; Fassbender, Michael; Radchenko, Valery; Engle, Jonathan Ward

Issue Date:: 2019-10-22

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1600190

Patent Number(s):: 10,450,336

Application Number:: 14/703,253

Assignee:: Triad National Security, LLC (Los Alamos, NM)

DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 05/04/2015

Country of Publication:: United States

Language:: English

Subject:: 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats


                    Wilson, Justin, Birnbaum, Eva, John, Kevin, Nortier, Francois, Fassbender, Michael, Radchenko, Valery, and Engle, Jonathan Ward. Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands.  United States: N. p., 2019. 
        Web.

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                    Wilson, Justin, Birnbaum, Eva, John, Kevin, Nortier, Francois, Fassbender, Michael, Radchenko, Valery, & Engle, Jonathan Ward. Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands.  United States.

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                    Wilson, Justin, Birnbaum, Eva, John, Kevin, Nortier, Francois, Fassbender, Michael, Radchenko, Valery, and Engle, Jonathan Ward. Tue .  
        "Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands".  United States.  https://www.osti.gov/servlets/purl/1600190.

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@article{osti_1600190,

  title        = {Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands},

  author       = {Wilson, Justin and Birnbaum, Eva and John, Kevin and Nortier, Francois and Fassbender, Michael and Radchenko, Valery and Engle, Jonathan Ward},

  abstractNote = {Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {10}

}

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Works referenced in this record:

Bismuth-213 generator and uses thereof
patent, August 2003

Scheinberg, David A.; Finn, Ronald D.; Ma, Dangshe
US Patent Document 6,603,127
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6603127

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Similar Records

Title: Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands

Abstract

Citation Formats

Bismuth-213 generator and uses thereof patent, August 2003

Bismuth-213 generator and uses thereof
patent, August 2003