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Title: TGF-.beta. antagonists as mitigators of radiation-induced tissue damage

A method for treating tissue damage caused by radiation is described by use of a TGF-.beta. antagonist, such as an anti-TGF-.beta. antibody or a TGF-.beta. latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.
Inventors:
 [1]
  1. (Oakland, CA)
Issue Date:
OSTI Identifier:
870891
Assignee:
Regents of University of California (Oakland, CA) LBNL
Patent Number(s):
US 5616561
Contract Number:
AC03-76SF00098
Research Org:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
Country of Publication:
United States
Language:
English
Subject:
tgf-; beta; antagonists; mitigators; radiation-induced; tissue; damage; method; treating; caused; radiation; described; antagonist; anti-tgf-; antibody; latency; associated; protein; administered; week; exposure; particularly; useful; mitigating; effects; breast; cancer; therapy; tissue damage; breast cancer; particularly useful; cancer therapy; damage caused; /514/

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