TGF-.beta. antagonists as mitigators of radiation-induced tissue damage

Barcellos-Hoff, Mary H

Title: TGF-.beta. antagonists as mitigators of radiation-induced tissue damage

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Abstract

A method for treating tissue damage caused by radiation is described by use of a TGF-.beta. antagonist, such as an anti-TGF-.beta. antibody or a TGF-.beta. latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

Inventors:

Barcellos-Hoff, Mary H ^[1]

Oakland, CA

Issue Date:: 1997-01-01

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

OSTI Identifier:: 870891

Patent Number(s):: 5616561

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/1709 - {from mammals}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K16/22 - against growth factors {

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DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: tgf-; beta; antagonists; mitigators; radiation-induced; tissue; damage; method; treating; caused; radiation; described; antagonist; anti-tgf-; antibody; latency; associated; protein; administered; week; exposure; particularly; useful; mitigating; effects; breast; cancer; therapy; tissue damage; breast cancer; particularly useful; cancer therapy; damage caused; /514/

Citation Formats


                    Barcellos-Hoff, Mary H. TGF-.beta. antagonists as mitigators of radiation-induced tissue damage.  United States: N. p., 1997. 
        Web.

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                    Barcellos-Hoff, Mary H. TGF-.beta. antagonists as mitigators of radiation-induced tissue damage.  United States.

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                    Barcellos-Hoff, Mary H. Wed .  
        "TGF-.beta. antagonists as mitigators of radiation-induced tissue damage".  United States.  https://www.osti.gov/servlets/purl/870891.

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@article{osti_870891,

  title        = {TGF-.beta. antagonists as mitigators of radiation-induced tissue damage},

  author       = {Barcellos-Hoff, Mary H},

  abstractNote = {A method for treating tissue damage caused by radiation is described by use of a TGF-.beta. antagonist, such as an anti-TGF-.beta. antibody or a TGF-.beta. latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {1}

}

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