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Title: TGF-{beta} antagonists as mitigators of radiation-induced tissue damage

Abstract

A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

Inventors:
Issue Date:
Research Org.:
University of California
OSTI Identifier:
462854
Patent Number(s):
5,616,561
Application Number:
PAN: 8-414,020; TRN: 97:007360
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 1 Apr 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIATION INJURIES; GROWTH FACTORS; MAMMARY GLANDS; RADIOTHERAPY; NEOPLASMS; RESPONSE MODIFYING FACTORS; BIOLOGICAL RADIATION EFFECTS; THERAPEUTIC USES

Citation Formats

Barcellos-Hoff, M H. TGF-{beta} antagonists as mitigators of radiation-induced tissue damage. United States: N. p., 1997. Web.
Barcellos-Hoff, M H. TGF-{beta} antagonists as mitigators of radiation-induced tissue damage. United States.
Barcellos-Hoff, M H. Tue . "TGF-{beta} antagonists as mitigators of radiation-induced tissue damage". United States.
@article{osti_462854,
title = {TGF-{beta} antagonists as mitigators of radiation-induced tissue damage},
author = {Barcellos-Hoff, M H},
abstractNote = {A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {4}
}