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Title: TGF-{beta} antagonists as mitigators of radiation-induced tissue damage

A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.
Inventors:
Issue Date:
OSTI Identifier:
462854
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550603; 560151; PA: EDB-97:063257; SN: 97001767260
Patent Number(s):
US 5,616,561/A/
Application Number:
PAN: 8-414,020; TRN: 97:007360
Contract Number:
AC03-76SF00098
Resource Relation:
Other Information: PBD: 1 Apr 1997
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIATION INJURIES; GROWTH FACTORS; MAMMARY GLANDS; RADIOTHERAPY; NEOPLASMS; RESPONSE MODIFYING FACTORS; BIOLOGICAL RADIATION EFFECTS; THERAPEUTIC USES