TGF-{beta} antagonists as mitigators of radiation-induced tissue damage

Barcellos-Hoff, M H

Title: TGF-{beta} antagonists as mitigators of radiation-induced tissue damage

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Abstract

A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

Inventors:: Barcellos-Hoff, M H

Issue Date:: 1997-04-01

Research Org.:: Univ. of California (United States)

OSTI Identifier:: 462854

Patent Number(s):: 5616561

Application Number:: PAN: 8-414,020; TRN: 97:007360

Assignee:: Univ. of California, Oakland, CA (United States)

DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Resource Relation:: Other Information: PBD: 1 Apr 1997

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIATION INJURIES; GROWTH FACTORS; MAMMARY GLANDS; RADIOTHERAPY; NEOPLASMS; RESPONSE MODIFYING FACTORS; BIOLOGICAL RADIATION EFFECTS; THERAPEUTIC USES

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                    Barcellos-Hoff, M H. TGF-{beta} antagonists as mitigators of radiation-induced tissue damage.  United States: N. p., 1997. 
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                    Barcellos-Hoff, M H. TGF-{beta} antagonists as mitigators of radiation-induced tissue damage.  United States.

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                    Barcellos-Hoff, M H. Tue .  
        "TGF-{beta} antagonists as mitigators of radiation-induced tissue damage".  United States.

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@article{osti_462854,

  title        = {TGF-{beta} antagonists as mitigators of radiation-induced tissue damage},

  author       = {Barcellos-Hoff, M H},

  abstractNote = {A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {4}

}

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