Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical

Katti, Kattesh V; Volkert, Wynn A; Ketring, Alan R; Singh, Prahlad R

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Title: Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical

Abstract

A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.

Inventors:

Katti, Kattesh V ^[1]; Volkert, Wynn A ^[1]; Ketring, Alan R ^[1]; Singh, Prahlad R ^[1]

Columbia, MO

Issue Date:: 1996-01-01

Research Org.:: Univ. of Missouri, Columbia, MO (United States)

OSTI Identifier:: 870416

Patent Number(s):: 5516940

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/28 - Compounds containing heavy metals
A61K31/66 - Phosphorus compounds
A61K31/675 - having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K49/103 - {the complex-forming compound being acyclic, e.g. DTPA}
A61K51/0478 - {complexes from non-cyclic ligands, e.g. EDTA, MAG3}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents
A61P43/00 - Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B59/004 - {Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic System
C07F13/005 - {Compounds without a metal-carbon linkage}
C07F15/0066 - {without a metal-carbon linkage}
C07F15/065 - {without a metal-carbon linkage}
C07F19/005 - {without metal-C linkages}
C07F7/003 - {without C-Metal linkages}
C07F7/30 - Germanium compounds
C07F9/065 - {Phosphoranes containing the structure P=N-}
C07F9/228 - {containing the structure P-N-N, e.g. azides, hydrazides}
C07F9/2491 - {containing the structure P
C07F9/4496 - {Compounds containing the structure P
C07F9/5355 - {Phosphoranes containing the structure P=N-}

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DOE Contract Number:: FG02-89ER60875

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: multifunctional; ligand; diagnostic; therapeutic; pharmaceutical; compound; method; comprises; phosphorous; germanium; core; hydrazine; forming; bonding; metal; extending; therapeutic pharmaceutical; pharmaceutical comprises; multifunctional ligand; /999/252/

Citation Formats


                    Katti, Kattesh V, Volkert, Wynn A, Ketring, Alan R, and Singh, Prahlad R. Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical.  United States: N. p., 1996. 
        Web.

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                    Katti, Kattesh V, Volkert, Wynn A, Ketring, Alan R, & Singh, Prahlad R. Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical.  United States.

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                    Katti, Kattesh V, Volkert, Wynn A, Ketring, Alan R, and Singh, Prahlad R. Mon .  
        "Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical".  United States.  https://www.osti.gov/servlets/purl/870416.

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@article{osti_870416,

  title        = {Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical},

  author       = {Katti, Kattesh V and Volkert, Wynn A and Ketring, Alan R and Singh, Prahlad R},

  abstractNote = {A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1996},

  month        = {1}

}

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Works referenced in this record:

Differential cellular catabolism of 111In, 90Y and 125I radiolabeled T101 anti-CD5 monoclonal antibody
journal, January 1990

Naruki, Yukihiko; Carrasquillo, Jorge A.; Reynolds, James C.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 17, Issue 2
https://doi.org/10.1016/0883-2897(90)90148-T

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8
journal, July 1990

Abrams, Michael J.; Larsen, Scott K.; Zubieta, Jon
Inorganica Chimica Acta, Vol. 173, Issue 2
https://doi.org/10.1016/S0020-1693(00)80203-0

The chemistry of 99mTc-labeled radiopharmaceuticals
journal, January 1990

Dewanjee, Mrinal K.
Seminars in Nuclear Medicine, Vol. 20, Issue 1
https://doi.org/10.1016/S0001-2998(05)80173-4

Heterocycles contenant du phosphore—XXIX
journal, January 1976

Majoral, J. P.; Kraemer, R.; Navech, J.
Tetrahedron, Vol. 32, Issue 21
https://doi.org/10.1016/0040-4020(76)88041-6

Current and future radiopharmaceuticals for brain imaging with single photon emission computed tomography
journal, October 1990

Kung, Hank F.; Ohmomo, Yoshiro; Kung, Mei-Ping
Seminars in Nuclear Medicine, Vol. 20, Issue 4
https://doi.org/10.1016/S0001-2998(05)80235-1

Production and Use of Prospective Radionuclides for Radioimmunotherapy
book, January 1988

Mausner, Leonard F.; Straub, Rita F.; Srivastava, Suresh C.
Radiolabeled Monoclonal Antibodies for Imaging and Therapy
https://doi.org/10.1007/978-1-4684-5538-0_12

Antibody radiolabeling, problems and promises
journal, January 1990

Hnatowich, D. J.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 17, Issue 1
https://doi.org/10.1016/0883-2897(90)90007-N

ESR spectra of seven-coordinated pentagonal bipyramidal copper(II) complexes
journal, January 1980

Nishida, Yuzo; Takahashi, Kazuhiro; Ida, Kazuhiko
Inorganica Chimica Acta, Vol. 45
https://doi.org/10.1016/S0020-1693(00)80115-2

Darstellung von Thiophosphoryltrihydrazid und 1-Phenyl-2-difluorthiophosphoryl-hydrazin
journal, July 1967

Horn, Hans-Georg; Glemser, Oskar
Chemische Berichte, Vol. 100, Issue 7
https://doi.org/10.1002/cber.19671000721

Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990

Parker, David
Chem. Soc. Rev., Vol. 19, Issue 3
https://doi.org/10.1039/CS9901900271

Die Stabilisierung von Tris(hydrazino)phosphan durch Komplexbildung / The Stabilisation of Tris(hydrazino)phosphane by Complex Formation
journal, June 1981

Nöth, Heinrich; Thorn, Volker
Zeitschrift für Naturforschung B, Vol. 36, Issue 6
https://doi.org/10.1515/znb-1981-0601

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver
journal, January 1988

Meares, Claude F.; McCall, Michael J.; Deshpande, Shrikant V.
International Journal of Cancer, Vol. 41, Issue S2
https://doi.org/10.1002/ijc.2910410723

Radiotherapeutic agents: Properties, dosimetry, and radiobiologic considerations
journal, April 1979

Saenger, Eugene L.; Kereiakes, James G.; Sodd, Vincent J.
Seminars in Nuclear Medicine, Vol. 9, Issue 2
https://doi.org/10.1016/S0001-2998(79)80038-0

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Similar Records

Title: Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical

Abstract

Citation Formats

Differential cellular catabolism of 111In, 90Y and 125I radiolabeled T101 anti-CD5 monoclonal antibody journal, January 1990

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 journal, July 1990

The chemistry of 99mTc-labeled radiopharmaceuticals journal, January 1990

Heterocycles contenant du phosphore—XXIX journal, January 1976

Current and future radiopharmaceuticals for brain imaging with single photon emission computed tomography journal, October 1990

Production and Use of Prospective Radionuclides for Radioimmunotherapy book, January 1988

Antibody radiolabeling, problems and promises journal, January 1990

ESR spectra of seven-coordinated pentagonal bipyramidal copper(II) complexes journal, January 1980

Darstellung von Thiophosphoryltrihydrazid und 1-Phenyl-2-difluorthiophosphoryl-hydrazin journal, July 1967

Tumour targeting with radiolabelled macrocycle–antibody conjugates journal, January 1990

Die Stabilisierung von Tris(hydrazino)phosphan durch Komplexbildung / The Stabilisation of Tris(hydrazino)phosphane by Complex Formation journal, June 1981

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver journal, January 1988

Radiotherapeutic agents: Properties, dosimetry, and radiobiologic considerations journal, April 1979

Differential cellular catabolism of 111In, 90Y and 125I radiolabeled T101 anti-CD5 monoclonal antibody
journal, January 1990

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8
journal, July 1990

The chemistry of 99mTc-labeled radiopharmaceuticals
journal, January 1990

Heterocycles contenant du phosphore—XXIX
journal, January 1976

Current and future radiopharmaceuticals for brain imaging with single photon emission computed tomography
journal, October 1990

Production and Use of Prospective Radionuclides for Radioimmunotherapy
book, January 1988

Antibody radiolabeling, problems and promises
journal, January 1990

ESR spectra of seven-coordinated pentagonal bipyramidal copper(II) complexes
journal, January 1980

Darstellung von Thiophosphoryltrihydrazid und 1-Phenyl-2-difluorthiophosphoryl-hydrazin
journal, July 1967

Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990

Die Stabilisierung von Tris(hydrazino)phosphan durch Komplexbildung / The Stabilisation of Tris(hydrazino)phosphane by Complex Formation
journal, June 1981

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver
journal, January 1988

Radiotherapeutic agents: Properties, dosimetry, and radiobiologic considerations
journal, April 1979