Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
Abstract
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.
- Inventors:
-
- Columbia, MO
- Issue Date:
- Research Org.:
- Univ. of Missouri, Columbia, MO (United States)
- OSTI Identifier:
- 872966
- Patent Number(s):
- 6054115
- Assignee:
- Curators of University of Missouri (Columbia, MO)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG02-89ER60875
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- hydroxymethyl; phosphine; compounds; diagnostic; therapeutic; pharmaceuticals; method; compound; pharmaceutical; comprises; functionalized; hydroxyalkyl; donor; sulfur; nitrogen; metal; combined; ligand; therapeutic pharmaceutical; hydroxyalkyl phosphine; metal combined; phosphine donor; phosphine compounds; pharmaceutical comprises; therapeutic pharmaceuticals; functionalized hydroxyalkyl; hydroxymethyl phosphine; /424/999/
Citation Formats
Katti, Kattesh V, Karra, Srinivasa Rao, Berning, Douglas E, Smith, C Jeffrey, Volkert, Wynn A, and Ketring, Alan R. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same. United States: N. p., 2000.
Web.
Katti, Kattesh V, Karra, Srinivasa Rao, Berning, Douglas E, Smith, C Jeffrey, Volkert, Wynn A, & Ketring, Alan R. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same. United States.
Katti, Kattesh V, Karra, Srinivasa Rao, Berning, Douglas E, Smith, C Jeffrey, Volkert, Wynn A, and Ketring, Alan R. Sat .
"Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same". United States. https://www.osti.gov/servlets/purl/872966.
@article{osti_872966,
title = {Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same},
author = {Katti, Kattesh V and Karra, Srinivasa Rao and Berning, Douglas E and Smith, C Jeffrey and Volkert, Wynn A and Ketring, Alan R},
abstractNote = {A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}
Works referenced in this record:
Syntheses and Structural Characterizations of Six-Coordinate Oxo-M(V) Complexes (M = Tc, Re) Containing a Tetradentate P2N2-Phosphino-Amido Ligand
journal, March 1995
- Tisato, Francesco; Refosco, Fiorenzo; Moresco, Annarosa
- Inorganic Chemistry, Vol. 34, Issue 7
Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8
journal, July 1990
- Abrams, Michael J.; Larsen, Scott K.; Zubieta, Jon
- Inorganica Chimica Acta, Vol. 173, Issue 2
Stereochemical Control of Transition Metal Complexes by Polyphosphine Ligands
journal, July 1994
- Mayer, Hermann A.; Kaska, William C.
- Chemical Reviews, Vol. 94, Issue 5
Coordination chemistry of phosphorus(III) and phosphorus(V) hydrazides
journal, January 1995
- Katti, Kattesh V.; Reddy, V. Sreenivasa; Singh, Prahlad R.
- Chemical Society Reviews, Vol. 24, Issue 2
In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP)
journal, July 1996
- Berning, D. E.; Katti, K. V.; Singh, P. R.
- Nuclear Medicine and Biology, Vol. 23, Issue 5
Synthesis, characterization, and electrochemical properties of tertiary diphosphine complexes of technetium: single-crystal structure of the prototype complex trans-[Tc(DPPE)2Br2]BF4
journal, June 1983
- Libson, Karen; Barnett, B. L.; Deutsch, Edward
- Inorganic Chemistry, Vol. 22, Issue 12
An isothiocyanato complex of technetium(II). Spectroelectrochemical and single-crystal x-ray structural studies on trans-[Tc(DPPE)2(NCS)2]0, where DPPE = 1,2-bis(diphenylphosphino)ethane
journal, August 1984
- Bandoli, Giuliano; Mazzi, Ulderico; Ichimura, Akio
- Inorganic Chemistry, Vol. 23, Issue 18
Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling
journal, November 1992
- Wilbur, D. Scott
- Bioconjugate Chemistry, Vol. 3, Issue 6
Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
journal, November 1992
- Rao, T. N.; Gustavson, Linda M.; Srinivasan, Ananthachari
- International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 8
An empirical correction for absorption anisotropy
journal, January 1995
- Blessing, R. H.
- Acta Crystallographica Section A Foundations of Crystallography, Vol. 51, Issue 1
Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis
journal, October 1999
- Ohtsuki, Katsuichi; Akashi, Koichi; Aoka, Yoshikazu
- European Journal of Nuclear Medicine and Molecular Imaging, Vol. 26, Issue 10
Chemical and physical properties of radionuclides
journal, January 1987
- Troutner, David E.
- International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 14, Issue 3
Water soluble, zero-valent, platinum–, palladium–, and nickel–P(CH 2 OH) 3 complexes:catalysts for the addition of PH 3 to CH 2 O
journal, January 1989
- Harrison, Karl N.; Hoye, Peter A. T.; Orpen, A. Guy
- J. Chem. Soc., Chem. Commun., Issue 16
Phase annealing in SHELX-90: direct methods for larger structures
journal, June 1990
- Sheldrick, G. M.
- Acta Crystallographica Section A Foundations of Crystallography, Vol. 46, Issue 6, p. 467-473
Medical Diagnostic Imaging with Complexes of 99mTc
journal, May 1987
- Clarke, Michael J.; Podbielski, Lisa
- Coordination Chemistry Reviews, Vol. 78
Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3
journal, July 1992
- Ellis, James W.; Harrison, Karl N.; Hoye, Peter A. T.
- Inorganic Chemistry, Vol. 31, Issue 14
Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2
journal, January 1996
- Reddy, V. Sreenivasa; Katti, Kattesh V.; Barnes, Charles L.
- Journal of the Chemical Society, Dalton Transactions, Issue 7
Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.
journal, April 1993
- Bickel, U.; Yoshikawa, T.; Landaw, E. M.
- Proceedings of the National Academy of Sciences, Vol. 90, Issue 7
The Preparation and Properties of [Re(amine) 4 O 2 ] + Type Ions
journal, June 1965
- Beard, John H.; Casey, Judith; Murmann, R. Kent
- Inorganic Chemistry, Vol. 4, Issue 6
New advances in the synthesis of a water-soluble triphosphine and the development of tripodally coordinated rhodium(I) and platinum(II) complexes
journal, January 1996
- Smith, C. Jeffrey; Redy, V. Sreenivasa; Katti, Kattesh V.
- Chemical Communications, Issue 22
Co-ordination of (o-aminophenyl)diphenylphosphine in complexes containing the [Mv= O]3+(M = Tc or Re) core
journal, January 1993
- Refosco, Fiorenzo; Tisato, Francesco; Bandoli, Giuliano
- Journal of the Chemical Society, Dalton Transactions, Issue 4
Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.
journal, June 1988
- Fritzberg, A. R.; Abrams, P. G.; Beaumier, P. L.
- Proceedings of the National Academy of Sciences, Vol. 85, Issue 11
Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR n Q 3–n (n= 0,1, or 2; R = Me, Et, Bu t , or Ph; Q = CH 2 OCOMe or CH 2 OH)
journal, January 1973
- Chatt, Joseph; Leigh, G. Jeffery; Slade, Roger M.
- J. Chem. Soc., Dalton Trans., Issue 19
Chemistry in environmentally benign media Part 1. Synthesis and characterization of 1,2-bis[bis(hydroxymethyl)phosphino]ethane (‘HMPE’). X-ray structure of [Pt{(HOH2C)2PCH2CH2P(CH2OH)2}2](Cl)2
journal, December 1995
- Reddy, V. Sreenivasa; Katti, Kattesh V.; Barnes, Charles L.
- Inorganica Chimica Acta, Vol. 240, Issue 1-2
Technetium electrochemistry. 2. Electrochemical and spectroelectrochemical studies of the bis(tertiary phosphine) (D) complexes trans-[TcIIID2X2]+ (X =chlorine or bromine)
journal, April 1984
- Ichimura, Akio; Heineman, William R.; Vanderheyden, Jean Luc
- Inorganic Chemistry, Vol. 23, Issue 9
Synthesis and characterization of cationic technetium complexes of 1,2-bis(dimethylphosphino)ethane (DMPE). Structure determinations of trans-[TcV(DMPE)2(OH)(O)](F3CSO3)2, trans-[TcIII(DMPE)2Cl2]F3CSO3, and [TcI(DMPE)3]+ using x-ray diffraction, EXAFS, and technetium-99 NMR
journal, September 1984
- Vanderheyden, Jean Luc; Ketring, Alan R.; Libson, Karen
- Inorganic Chemistry, Vol. 23, Issue 20
Antibody radiolabeling, problems and promises
journal, January 1990
- Hnatowich, D. J.
- International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 17, Issue 1
Comparison of the chemical and biological properties of trans-[Tc(DMPE)2Cl2]+ and trans-[Re(DMPE)2Cl2]+, where DMPE = 1,2-bis(dimethylphosphino)ethane. Single-crystal structural analysis of trans-[Re(DMPE)2Cl2]PF6
journal, May 1985
- Vanderheyden, Jean Luc; Heeg, Mary Jane; Deutsch, Edward
- Inorganic Chemistry, Vol. 24, Issue 11
Aspects of the Chemistry of Technetium Phosphine Complexes
journal, January 1993
- Deutsch, Edward
- Radiochimica Acta, Vol. 63, Issue s1
Coordination compounds in nuclear medicine
journal, May 1993
- Jurisson, S.; Berning, D.; Jia, Wei.
- Chemical Reviews, Vol. 93, Issue 3
Synthesis and characterization of dioxorhenium complexes derived from water-soluble diphosphine tetraphosphonates
journal, January 1996
- Reddy, V. Sreenivasa; Katti, Kattesh V.; Volkert, Wynn A.
- Journal of the Chemical Society, Dalton Transactions, Issue 23
Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands
journal, September 1991
- Gustavson, Linda M.; Rao, T. N.; Jones, David S.
- Tetrahedron Letters, Vol. 32, Issue 40
Recent Developments in Peptide Drug Delivery to the Brain
journal, July 1992
- Pardridge, William M.
- Pharmacology & Toxicology, Vol. 71, Issue 1
Chemistry in Environmentally Benign Media. 3. 1 Synthesis and Characterization of Rhenium(V) Complexes Derived from Novel Water-Soluble (Hydroxymethyl)phosphines. Crystal Structures of [Re(O) 2 {(HOH 2 C) 2 PC 6 H 4 P(CH 2 OH) 2 } 2 ]I and [Re(O) 2 {(HOH 2 C) 2 PCH 2 CH 2 P(CH 2 OH) 2 } 2 ]Cl
journal, January 1996
- Reddy, V. Sreenivasa; Berning, Douglas E.; Katti, Kattesh V.
- Inorganic Chemistry, Vol. 35, Issue 7
Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990
- Parker, David
- Chem. Soc. Rev., Vol. 19, Issue 3
Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver
journal, January 1988
- Meares, Claude F.; McCall, Michael J.; Deshpande, Shrikant V.
- International Journal of Cancer, Vol. 41, Issue S2