Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Miura, Michiko; Slatkin, Daniel N

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Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Abstract

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

Inventors:

Miura, Michiko ^[1]; Slatkin, Daniel N ^[2]

Hampton Bays, NY
Southold, NY

Issue Date:: Tue Oct 03 00:00:00 EDT 1995

Research Org.:: Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:: 870091

Patent Number(s):: 5455022

Application Number:: 08/118,300

Assignee:: Associated Universities, Inc. (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS
C01B35/14 - Compounds containing boron and nitrogen, phosphorus, sulfur, selenium or tellurium

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DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: halogenated; sulfidohydroboranes; nuclear; medicine; boron; neutron; capture; therapy; method; performing; treatment; tumors; disclosed; administering; patient; iodinated; sulfidohydroborane; boron-10-containing; compound; site; tumor; localized; visualizing; increased; concentration; iodine; labelled; targeted; irradiated; beam; neutrons; energy; distribution; effective; destruction; occurs; due; particle; irradiation; tissue; secondary; incident; captured; boron-10; nuclei; especially; suitable; preferred; embodiment; formula; na; 12; 11; ssb; pharmaceutically; acceptable; salt; administered; cancer; occurs due; containing compound; distribution effective; nuclear medicine; preferred embodiment; neutron capture; energy distribution; boron neutron; capture therapy; especially suitable; pharmaceutically acceptable; tissue secondary; tumor occurs; boron-10-containing compound; boron-10 nuclei; cancer patient; performing boron; acceptable salt; particle irradiation; incident neutrons; targeted tumor; halogenated sulfidohydroboranes; labelled compound; iodinated sulfidohydroboranes; iodinated sulfidohydroborane; iodine labelled; increased concentration; formula na; /424/423/

Citation Formats


                    Miura, Michiko, and Slatkin, Daniel N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy.  United States: N. p., 1995. 
        Web.

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                    Miura, Michiko, & Slatkin, Daniel N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy.  United States.

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                    Miura, Michiko, and Slatkin, Daniel N. Tue .  
        "Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy".  United States.  https://www.osti.gov/servlets/purl/870091.

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@article{osti_870091,

  title        = {Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy},

  author       = {Miura, Michiko and Slatkin, Daniel N},

  abstractNote = {A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Oct 03 00:00:00 EDT 1995},

  month        = {Tue Oct 03 00:00:00 EDT 1995}

}

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Works referenced in this record:

Uranium-loaded apoferritin with antibodies attached: molecular design for uranium neutron-capture therapy.
journal, November 1992

Hainfeld, J. F.
Proceedings of the National Academy of Sciences, Vol. 89, Issue 22
https://doi.org/10.1073/pnas.89.22.11064

Boron uptake in melanoma, cerebrum and blood from Na2B12H11SH and Na4B24H22S2 administered to mice
journal, May 1986

Slatkin, Daniel; Micca, Peggy; Forman, Arthur
Biochemical Pharmacology, Vol. 35, Issue 10
https://doi.org/10.1016/0006-2952(86)90342-4

An Extravascular Component of Contrast Enhancement in Cranial Computed Tomography: Part I: The Tissue—Blood Ratio of Contrast Enhancement
journal, December 1975

Gado, Mokhtar H.; Phelps, Michael E.; Coleman, R. Edward
Radiology, Vol. 117, Issue 3
https://doi.org/10.1148/117.3.589

A History of Boron Neutron Capture Therapy of Brain Tumours: Postulation of a Brain Radiation dose Tolerance Limit
journal, January 1991

Slatkin, Daniel N.
Brain, Vol. 114, Issue 4
https://doi.org/10.1093/brain/114.4.1609

Chemistry of Boranes. IX. Halogenation of B ₁₀ H ₁₀ ^-2 and B ₁₂ H ₁₂ ^-2
journal, February 1964

Knoth, W. H.; Miller, H. C.; Sauer, J. C.
Inorganic Chemistry, Vol. 3, Issue 2
https://doi.org/10.1021/ic50012a002

Boron neutron capture therapy of intracerebral rat gliosarcomas.
journal, December 1990

Joel, D. D.; Fairchild, R. G.; Laissue, J. A.
Proceedings of the National Academy of Sciences, Vol. 87, Issue 24
https://doi.org/10.1073/pnas.87.24.9808

Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice
journal, February 1992

Miura, Michiko; Micca, Peggy L.; Heinrichs, John C.
Biochemical Pharmacology, Vol. 43, Issue 3
https://doi.org/10.1016/0006-2952(92)90565-Z

Synthesis and chemistry of mercaptoundecahydro-closo-dodecaborate(2-)
journal, October 1978

Tolpin, Eugene I.; Wellum, Glyn R.; Berley, Steven A.
Inorganic Chemistry, Vol. 17, Issue 10
https://doi.org/10.1021/ic50188a037

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Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Patent Miura, Michiko [Hampton Bays, NY]; Slatkin, Daniel N [Southold, NY]

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less

Similar Records

Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Abstract

Citation Formats

Uranium-loaded apoferritin with antibodies attached: molecular design for uranium neutron-capture therapy. journal, November 1992

Boron uptake in melanoma, cerebrum and blood from Na2B12H11SH and Na4B24H22S2 administered to mice journal, May 1986

An Extravascular Component of Contrast Enhancement in Cranial Computed Tomography: Part I: The Tissue—Blood Ratio of Contrast Enhancement journal, December 1975

A History of Boron Neutron Capture Therapy of Brain Tumours: Postulation of a Brain Radiation dose Tolerance Limit journal, January 1991

Chemistry of Boranes. IX. Halogenation of B 10 H 10 -2 and B 12 H 12 -2 journal, February 1964

Boron neutron capture therapy of intracerebral rat gliosarcomas. journal, December 1990

Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice journal, February 1992

Synthesis and chemistry of mercaptoundecahydro-closo-dodecaborate(2-) journal, October 1978

Uranium-loaded apoferritin with antibodies attached: molecular design for uranium neutron-capture therapy.
journal, November 1992

Boron uptake in melanoma, cerebrum and blood from Na2B12H11SH and Na4B24H22S2 administered to mice
journal, May 1986

An Extravascular Component of Contrast Enhancement in Cranial Computed Tomography: Part I: The Tissue—Blood Ratio of Contrast Enhancement
journal, December 1975

A History of Boron Neutron Capture Therapy of Brain Tumours: Postulation of a Brain Radiation dose Tolerance Limit
journal, January 1991

Chemistry of Boranes. IX. Halogenation of B ₁₀ H ₁₀ ^-2 and B ₁₂ H ₁₂ ^-2
journal, February 1964

Boron neutron capture therapy of intracerebral rat gliosarcomas.
journal, December 1990

Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice
journal, February 1992

Synthesis and chemistry of mercaptoundecahydro-closo-dodecaborate(2-)
journal, October 1978