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Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Abstract

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

Inventors:
 [1];  [2]
  1. (Hampton Bays, NY)
  2. (Southold, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
871084
Patent Number(s):
5653957
Application Number:
08/740693
Assignee:
Associated Universities, Inc. (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
halogenated; sulfidohydroboranes; nuclear; medicine; boron; neutron; capture; therapy; method; performing; treatment; tumors; disclosed; administering; patient; iodinated; sulfidohydroborane; boron-10-containing; compound; site; tumor; localized; visualizing; increased; concentration; iodine; labelled; targeted; irradiated; beam; neutrons; energy; distribution; effective; destruction; occurs; due; particle; irradiation; tissue; secondary; incident; captured; boron-10; nuclei; especially; suitable; preferred; embodiment; formula; na; 12; 11; ssb; pharmaceutically; acceptable; salt; administered; cancer; occurs due; containing compound; distribution effective; nuclear medicine; preferred embodiment; neutron capture; energy distribution; boron neutron; capture therapy; especially suitable; pharmaceutically acceptable; tissue secondary; tumor occurs; boron-10-containing compound; boron-10 nuclei; cancer patient; performing boron; acceptable salt; particle irradiation; incident neutrons; targeted tumor; halogenated sulfidohydroboranes; labelled compound; iodinated sulfidohydroboranes; iodinated sulfidohydroborane; iodine labelled; increased concentration; formula na; /424/

Citation Formats

Miura, Michiko, and Slatkin, Daniel N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy. United States: N. p., 1997. Web.
Miura, Michiko, & Slatkin, Daniel N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy. United States.
Miura, Michiko, and Slatkin, Daniel N. Tue . "Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy". United States. https://www.osti.gov/servlets/purl/871084.
@article{osti_871084,
title = {Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy},
author = {Miura, Michiko and Slatkin, Daniel N.},
abstractNote = {A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {8}
}

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