Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Miura, Michiko; Slatkin, Daniel N

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Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Abstract

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

Inventors:

Miura, Michiko ^[1]; Slatkin, Daniel N ^[2]

Hampton Bays, NY
Southold, NY

Issue Date:: 1997-08-05

Research Org.:: Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:: 871084

Patent Number(s):: 5653957

Application Number:: 08/740693

Assignee:: Associated Universities, Inc. (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS
C01B35/14 - Compounds containing boron and nitrogen, phosphorus, sulfur, selenium or tellurium

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DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: halogenated; sulfidohydroboranes; nuclear; medicine; boron; neutron; capture; therapy; method; performing; treatment; tumors; disclosed; administering; patient; iodinated; sulfidohydroborane; boron-10-containing; compound; site; tumor; localized; visualizing; increased; concentration; iodine; labelled; targeted; irradiated; beam; neutrons; energy; distribution; effective; destruction; occurs; due; particle; irradiation; tissue; secondary; incident; captured; boron-10; nuclei; especially; suitable; preferred; embodiment; formula; na; 12; 11; ssb; pharmaceutically; acceptable; salt; administered; cancer; occurs due; containing compound; distribution effective; nuclear medicine; preferred embodiment; neutron capture; energy distribution; boron neutron; capture therapy; especially suitable; pharmaceutically acceptable; tissue secondary; tumor occurs; boron-10-containing compound; boron-10 nuclei; cancer patient; performing boron; acceptable salt; particle irradiation; incident neutrons; targeted tumor; halogenated sulfidohydroboranes; labelled compound; iodinated sulfidohydroboranes; iodinated sulfidohydroborane; iodine labelled; increased concentration; formula na; /424/

Citation Formats


                    Miura, Michiko, and Slatkin, Daniel N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy.  United States: N. p., 1997. 
        Web.

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                    Miura, Michiko, & Slatkin, Daniel N. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy.  United States.

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                    Miura, Michiko, and Slatkin, Daniel N. Tue .  
        "Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy".  United States.  https://www.osti.gov/servlets/purl/871084.

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@article{osti_871084,

  title        = {Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy},

  author       = {Miura, Michiko and Slatkin, Daniel N},

  abstractNote = {A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {8}

}

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Works referenced in this record:

Diazonium and Carbonyl Derivatives of Polyhedral Boranes
journal, January 1964

Knoth, W. H.; Sauer, J. C.; Miller, H. C.
Journal of the American Chemical Society, Vol. 86, Issue 1
https://doi.org/10.1021/ja01055a027

Chemistry of Boranes. IX. Halogenation of B ₁₀ H ₁₀ ^-2 and B ₁₂ H ₁₂ ^-2
journal, February 1964

Knoth, W. H.; Miller, H. C.; Sauer, J. C.
Inorganic Chemistry, Vol. 3, Issue 2
https://doi.org/10.1021/ic50012a002

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Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Patent Miura, Michiko [Hampton Bays, NY]; Slatkin, Daniel N [Southold, NY]

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
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Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less
Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

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A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitablemore » « less

Similar Records

Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Abstract

Citation Formats

Diazonium and Carbonyl Derivatives of Polyhedral Boranes journal, January 1964

Chemistry of Boranes. IX. Halogenation of B 10 H 10 -2 and B 12 H 12 -2 journal, February 1964

Diazonium and Carbonyl Derivatives of Polyhedral Boranes
journal, January 1964

Chemistry of Boranes. IX. Halogenation of B ₁₀ H ₁₀ ^-2 and B ₁₂ H ₁₂ ^-2
journal, February 1964