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Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.
Inventors:
;
Issue Date:
OSTI Identifier:
106704
Assignee:
Associated Universities, Inc., Washington, DC (United States) PTO; SCA: 550601; 550604; PA: EDB-95:138213; SN: 95001461629
Patent Number(s):
US 5,455,022/A/
Application Number:
PAN: 8-118,300
Contract Number:
AC02-76CH00016
Resource Relation:
Other Information: PBD: 3 Oct 1995
Research Org:
Associated Universities Inc
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; NEOPLASMS; NEUTRON CAPTURE THERAPY; BORON 10

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