Porphyrins for boron neutron capture therapy
Abstract
Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.
- Inventors:
-
- Center Moriches, NY
- Bremen, DE
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 867537
- Patent Number(s):
- 4959356
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- porphyrins; boron; neutron; capture; therapy; novel; compounds; treatment; brain; tumors; disclosed; method; preparing; pharmaceutical; compositions; containing; water; soluble; non-toxic; non-labile; boronated; significant; uptake; retention; pharmaceutical compositions; water soluble; neutron capture; boron neutron; capture therapy; compositions containing; novel compounds; pharmaceutical composition; compositions contain; novel compound; brain tumors; boronated porphyrins; /424/999/
Citation Formats
Miura, Michiko, and Gabel, Detlef. Porphyrins for boron neutron capture therapy. United States: N. p., 1990.
Web.
Miura, Michiko, & Gabel, Detlef. Porphyrins for boron neutron capture therapy. United States.
Miura, Michiko, and Gabel, Detlef. Mon .
"Porphyrins for boron neutron capture therapy". United States. https://www.osti.gov/servlets/purl/867537.
@article{osti_867537,
title = {Porphyrins for boron neutron capture therapy},
author = {Miura, Michiko and Gabel, Detlef},
abstractNote = {Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}
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