Chemiresistor urea sensor
Abstract
A sensor is disclosed to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects. 16 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 563679
- Patent Number(s):
- 5698083
- Application Number:
- PAN: 8-517,011
- Assignee:
- Univ. of California, Oakland, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 16 Dec 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; UREA; MEASURING INSTRUMENTS; MEASURING METHODS; DIALYSIS; DESIGN; UREASE
Citation Formats
Glass, R S. Chemiresistor urea sensor. United States: N. p., 1997.
Web.
Glass, R S. Chemiresistor urea sensor. United States.
Glass, R S. Tue .
"Chemiresistor urea sensor". United States.
@article{osti_563679,
title = {Chemiresistor urea sensor},
author = {Glass, R S},
abstractNote = {A sensor is disclosed to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects. 16 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 16 00:00:00 EST 1997},
month = {Tue Dec 16 00:00:00 EST 1997}
}