Chemiresistor urea sensor

Patent · Wed Jan 01 00:00:00 EST 1997

OSTI ID:871276

Glass, Robert S ^[1]

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1. Livermore, CA

A sensor to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5698083
• OSTI ID: 871276
• Country of Publication: United States
• Language: English

Related Subjects

chemiresistor
urea
sensor
detect
quantify
fluids
resulting
hemodialysis
procedures
blood
based
consists
interdigitated
array
metal
fingers
resistance
measured
fabricated
suitable
substrate
surface
covered
coating
containing
enzyme
urease
catalyzes
hydrolysis
form
ammonium
bicarbonate
hydroxide-chemical
products
provide
basis
signal
typical
application
bedside
conjunction
appropriate
electronics
computer
determine
endpoint
utilized
reference
contain
connected
differential
measurement
arrangement
cancel
fluctuations
due
background
effects
measured signal
typical application
suitable substrate
resistance measured
appropriate electronics
chemical products
chemical product
coating containing
fluids resulting
hemodialysis procedures
urea sensor
differential measurement
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