Chemiresistor urea sensor
Abstract
A sensor to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects.
- Inventors:
-
- Livermore, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 871276
- Patent Number(s):
- 5698083
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- chemiresistor; urea; sensor; detect; quantify; fluids; resulting; hemodialysis; procedures; blood; based; consists; interdigitated; array; metal; fingers; resistance; measured; fabricated; suitable; substrate; surface; covered; coating; containing; enzyme; urease; catalyzes; hydrolysis; form; ammonium; bicarbonate; hydroxide-chemical; products; provide; basis; signal; typical; application; bedside; conjunction; appropriate; electronics; computer; determine; endpoint; utilized; reference; contain; connected; differential; measurement; arrangement; cancel; fluctuations; due; background; effects; measured signal; typical application; suitable substrate; resistance measured; appropriate electronics; chemical products; chemical product; coating containing; fluids resulting; hemodialysis procedures; urea sensor; differential measurement; /204/422/435/436/
Citation Formats
Glass, Robert S. Chemiresistor urea sensor. United States: N. p., 1997.
Web.
Glass, Robert S. Chemiresistor urea sensor. United States.
Glass, Robert S. Wed .
"Chemiresistor urea sensor". United States. https://www.osti.gov/servlets/purl/871276.
@article{osti_871276,
title = {Chemiresistor urea sensor},
author = {Glass, Robert S},
abstractNote = {A sensor to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}