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Title: Chemiresistor urea sensor

A sensor to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects.
Inventors:
 [1]
  1. (Livermore, CA)
Issue Date:
OSTI Identifier:
871276
Assignee:
Regents of University of California (Oakland, CA) LLNL
Patent Number(s):
US 5698083
Contract Number:
W-7405-ENG-48
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Country of Publication:
United States
Language:
English
Subject:
chemiresistor; urea; sensor; detect; quantify; fluids; resulting; hemodialysis; procedures; blood; based; consists; interdigitated; array; metal; fingers; resistance; measured; fabricated; suitable; substrate; surface; covered; coating; containing; enzyme; urease; catalyzes; hydrolysis; form; ammonium; bicarbonate; hydroxide-chemical; products; provide; basis; signal; typical; application; bedside; conjunction; appropriate; electronics; computer; determine; endpoint; utilized; reference; contain; connected; differential; measurement; arrangement; cancel; fluctuations; due; background; effects; measured signal; typical application; suitable substrate; resistance measured; appropriate electronics; chemical products; chemical product; coating containing; fluids resulting; hemodialysis procedures; urea sensor; differential measurement; /204/422/435/436/

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