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Title: Co-factor activated recombinant adenovirus proteinases

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying the peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described. 29 figs.
Inventors:
;
Issue Date:
OSTI Identifier:
288025
Assignee:
Associated Universities, Inc., Washington, DC (United States) PTO; SCA: 550200; PA: EDB-96:137351; SN: 96001636045
Patent Number(s):
US 5,543,264/A/
Application Number:
PAN: 8-155,171
Contract Number:
AC02-76CH00016
Resource Relation:
Other Information: PBD: 6 Aug 1996
Research Org:
Associated Universities Inc
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PEPTIDE HYDROLASES; CHEMICAL PREPARATION; ADENOVIRUS; ANTIBODIES; ENZYME ACTIVITY; IMMUNE REACTIONS

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