skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Co-factor activated recombinant adenovirus proteinases

Abstract

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Inventors:
 [1];  [2]
  1. Stony Brook, NY
  2. Shoreham, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
870544
Patent Number(s):
5543264
Application Number:
US patent applicaiton 08/155,171
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
co-factor; activated; recombinant; adenovirus; proteinases; application; describes; methods; expression; constructs; producing; activatable; purified; purification; described; obtaining; included; isolated; peptide; cofactors; proteinase; activity; purifying; identifying; antibodies; immunoreactive; immunospecific; preparing; related; materials; related method; recombinant adenovirus; application describes; adenovirus proteinases; related methods; antibodies immunoreactive; isolated peptide; expression constructs; activatable recombinant; purified activatable; describes methods; producing activatable; activated recombinant; adenovirus proteinase; /435/999/

Citation Formats

Anderson, Carl W, and Mangel, Walter F. Co-factor activated recombinant adenovirus proteinases. United States: N. p., 1996. Web.
Anderson, Carl W, & Mangel, Walter F. Co-factor activated recombinant adenovirus proteinases. United States.
Anderson, Carl W, and Mangel, Walter F. Tue . "Co-factor activated recombinant adenovirus proteinases". United States. https://www.osti.gov/servlets/purl/870544.
@article{osti_870544,
title = {Co-factor activated recombinant adenovirus proteinases},
author = {Anderson, Carl W and Mangel, Walter F},
abstractNote = {This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {8}
}

Patent:

Save / Share:

Works referenced in this record:

The proteinase polypeptide of adenovirus serotype 2 virions
journal, July 1990


Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity
journal, January 1993


Characterization of the adenovirus 2 virion protein, Mu
journal, October 1989


Adenovirus type 2 endopeptidase: an unusual phosphoprotein enzyme matured by autocatalysis.
journal, February 1987


Gly-Gly-X, a Novel Consensus Sequence for the Proteolytic Processing of Viral and Cellular Proteins
journal, June 1989


In vitro cleavage specificity of the adenovirus type 2 proteinase
journal, March 1983


The adenovirus protease is activated by a virus-coded disulphide-linked peptide
journal, January 1993


Adenovirus type 2 precursor proteins are cleaved by proteinases of other adenoviruses
journal, November 1990


The active adenovirus protease is the intact L3 23K protein
journal, July 1993


Characterization of the Adenovirus Proteinase: Substrate Specificity
journal, December 1989


Isolation and properties of adenovirus type 2 proteinase.
journal, January 1993


Genetic identification of a endoproteinase endoded by the adenovirus genome
journal, June 1983