Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea
Abstract
The present invention provides for a novel recombinant or isolated nucleic acid useful for integrating or being maintained in an Archaea or acidophilic hyperthermophilic eubacteria. The nucleic acid encodes a nucleotide sequence that is capable of stably integrating into the chromosome of a host cell, or being maintained as an extrachromosomal element in a host cell, that is an Archea, and a nucleotide sequence of interest. The present invention also provides for an Archaea host cell comprising the nucleic acid stably integrated into the chromosome or maintained episomally in the host cell, and a method of expressing the nucleotide sequence of interest in the host cell and/or directing glycosylation, multimerization, and/or membrane association or integration.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1823989
- Patent Number(s):
- 11015181
- Application Number:
- 16/105,930
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 08/20/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Yannone, Steven M., and Barnebey, Adam. Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea. United States: N. p., 2021.
Web.
Yannone, Steven M., & Barnebey, Adam. Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea. United States.
Yannone, Steven M., and Barnebey, Adam. Tue .
"Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea". United States. https://www.osti.gov/servlets/purl/1823989.
@article{osti_1823989,
title = {Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea},
author = {Yannone, Steven M. and Barnebey, Adam},
abstractNote = {The present invention provides for a novel recombinant or isolated nucleic acid useful for integrating or being maintained in an Archaea or acidophilic hyperthermophilic eubacteria. The nucleic acid encodes a nucleotide sequence that is capable of stably integrating into the chromosome of a host cell, or being maintained as an extrachromosomal element in a host cell, that is an Archea, and a nucleotide sequence of interest. The present invention also provides for an Archaea host cell comprising the nucleic acid stably integrated into the chromosome or maintained episomally in the host cell, and a method of expressing the nucleotide sequence of interest in the host cell and/or directing glycosylation, multimerization, and/or membrane association or integration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 25 00:00:00 EDT 2021},
month = {Tue May 25 00:00:00 EDT 2021}
}
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