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Title: Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea

The present invention provides for a novel recombinant or isolated nucleic acid useful for integrating or being maintained in an Archaea or acidophilic hyperthermophilic eubacteria. The nucleic acid encodes a nucleotide sequence that is capable of stably integrating into the chromosome of a host cell, or being maintained as an extrachromosomal element in a host cell, that is an Archea, and a nucleotide sequence of interest. The present invention also provides for an Archaea host cell comprising the nucleic acid stably integrated into the chromosome or maintained episomally in the host cell, and a method of expressing the nucleotide sequence of interest in the host cell and/or directing glycosylation, multimerization, and/or membrane association or integration.
Issue Date:
OSTI Identifier:
The Regents of the University of California (Oakland, CA) LBNLSCH
Patent Number(s):
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Resource Relation:
Patent File Date: 2013 Nov 21
Research Org:
Lawrence Berkeley National Laboratory, E-Scholarship Repository, Berkeley, CA (United States)
Sponsoring Org:
Country of Publication:
United States