Advanced drug development and manufacturing
Abstract
X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1771770
- Patent Number(s):
- 10877035
- Application Number:
- 14/693,094
- Assignee:
- ICAGEN, LLC (San Diego, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/22/2015
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Birnbaum, Eva R., Koppisch, Andrew T., Baldwin, Sharon M., Warner, Benjamin P., McCleskey, T. Mark, Berger, Jennifer A., Stewart, Jeffrey J., Harris, Michael N., and Burrell, Anthony K. Advanced drug development and manufacturing. United States: N. p., 2020.
Web.
Birnbaum, Eva R., Koppisch, Andrew T., Baldwin, Sharon M., Warner, Benjamin P., McCleskey, T. Mark, Berger, Jennifer A., Stewart, Jeffrey J., Harris, Michael N., & Burrell, Anthony K. Advanced drug development and manufacturing. United States.
Birnbaum, Eva R., Koppisch, Andrew T., Baldwin, Sharon M., Warner, Benjamin P., McCleskey, T. Mark, Berger, Jennifer A., Stewart, Jeffrey J., Harris, Michael N., and Burrell, Anthony K. Tue .
"Advanced drug development and manufacturing". United States. https://www.osti.gov/servlets/purl/1771770.
@article{osti_1771770,
title = {Advanced drug development and manufacturing},
author = {Birnbaum, Eva R. and Koppisch, Andrew T. and Baldwin, Sharon M. and Warner, Benjamin P. and McCleskey, T. Mark and Berger, Jennifer A. and Stewart, Jeffrey J. and Harris, Michael N. and Burrell, Anthony K.},
abstractNote = {X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 29 00:00:00 EST 2020},
month = {Tue Dec 29 00:00:00 EST 2020}
}
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Works referenced in this record:
Proteomics in drug discovery
journal, August 2002
- Burbaum, Jonathan; Tobal, Gabriela M.
- Current Opinion in Chemical Biology, Vol. 6, Issue 4, p. 427-433
Multivariate calibrations for the SR-TXRF determination of trace concentrations of lead and arsenic in the presence of bromine
journal, January 2005
- Nagata, Noemi; Peralta-Zamora, Patricio G.; Poppi, Ronei J.
- X-Ray Spectrometry, Vol. 35, Issue 1
Printing Proteins as Microarrays for High-Throughput Function Determination
journal, September 2000
- MacBeath, Gavin; Schreiber, Stuart L.
- Science, Vol. 289, Issue 5485
Protein Microarrays to Detect Protein–Protein Interactions Using Red and Green Fluorescent Proteins
journal, July 2002
- Kukar, Thomas; Eckenrode, Sarah; Gu, Yunrong
- Analytical Biochemistry, Vol. 306, Issue 1
Receptor polypeptides and their production and uses
patent, June 1993
- Cox, Edward T.; Mather, Jennie P.; Sliwkowski, Mary B.
- US Patent Document 5,216,126
Apparatus for screening compound libraries
patent, May 2002
- Hindsgaul, Ole; Schriemer, David C.
- US Patent Document 6,395,169
Flow method and apparatus for screening chemicals using micro x-ray fluorescence
patent-application, September 2005
- Havrilla, George J.; Miller, Thomasin C.; Warner, Benjamin P.
- US Patent Application 11/125036; 20050214847
Method for detecting binding events using micro-X-ray fluorescence spectrometry
patent-application, February 2003
- Warner, Benjamin P.; Havrilla, George J.; Mann, Grace
- US Patent Application 09/859701; 20030027129
Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase † , ‡
journal, May 2004
- Johansson, Eva; Neuhard, Jan; Willemoës, Martin
- Biochemistry, Vol. 43, Issue 20
Method and apparatus for managing confidential information
patent-application, January 2005
- Bowers, Charles R.
- US Patent Application 10/623337; 20050015596
Novel detection strategies for drug discovery
journal, September 2002
- Hemmilä, Ilkka A.; Hurskainen, Pertti
- Drug Discovery Today, Vol. 7, Issue 18, p. S150-S156
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
journal, January 1997
- Lipinski, Christopher A.; Lombardo, Franco; Dominy, Beryl W.
- Advanced Drug Delivery Reviews, Vol. 23, Issue 1-3
Thermal and fluidic cycling device for nucleic acid hybridization
patent, August 2002
- Custance, Aaron; Parker, Jonathan I.
- US Patent Document 6,432,696
Method for the preparation of a material with high water and salt solutions absorbency
patent, February 2000
- Westerink, Jan Barend; Boerstoel, Hanneke; Maatman, Hendrik
- US Patent Document 6,027,536
Secure records storage and retrieval system and method
patent-application, January 2003
- Bailey, Steven; Masson, Robert; Rosemeyer, John
- US Patent Application 10/202793; 20030023562
Drug development and manufacturing
patent-application, November 2004
- Warner, Benjamin P.; McCleskey, T. Mark; Burrell, Anthony K.
- US Patent Application 10/880388; 20040235059
Analysis of surface immobilized polymers utilizing microfluorescence detection
patent, May 1999
- Dower, William J.; Fodor, Stephen P. A.
- US Patent Document 5,902,723
The theoretical derivation of fluorescent X-ray intensities from mixtures
journal, January 1955
- Sherman, Jacob
- Spectrochimica Acta, Vol. 7, p. 283-306
Thin film sample support
patent, September 1999
- Turner, D. Clark; Robbins, Arthur A.; Wilson, Alisa A.
- US Patent Document 5,958,345
Developing a Strategy for Activity-Based Detection of Enzymes in a Protein Microarray
journal, March 2003
- Chen, Grace Y. J.; Uttamchandani, Mahesh; Zhu, Qing
- ChemBioChem, Vol. 4, Issue 4, p. 336-339
Information access system, device and method
patent-application, July 2004
- Cavers, F. Mervyn; Dearth, Stephen E.
- US Patent Application 10/445873; 20040128518
Protein biochips for differential profiling
journal, February 2001
- Fung, Eric T.; Thulasiraman, Vanitha; Weinberger, Scot R.
- Current Opinion in Biotechnology, Vol. 12, Issue 1
Evaluation of the protein concentration in enzymes via determination of sulfur by total reflection X-ray fluorescence spectrometry — limitations of the method
journal, November 2001
- Mertens, M.; Rittmeyer, C.; Kolbesen, B. O.
- Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 56, Issue 11, p. 2157-2164
Flow method and apparatus for screening chemicals using micro x-ray fluorescence
patent-application, January 2004
- Havrilla, George J.; Miller, Thomasim C.; Warner, Benjamin P.
- US Patent Application 10/206524; 20040017884
A streptavidin-metallothionein chimera that allows specific labeling of biological materials with many different heavy metal ions.
journal, March 1992
- Sano, T.; Glazer, A. N.; Cantor, C. R.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 5
Method for identifying compounds in a chemical mixture
patent, November 2000
- Annis, D. Allen; Birnbaum, Mark; Birnbaum, Seth
- US Patent Document 6,147,344
Protein chip technology
journal, February 2003
- Zhu, Heng; Snyder, Michael
- Current Opinion in Chemical Biology, Vol. 7, Issue 1
Secondary alcohol dehydrogenase enzyme and use thereof
patent, December 1980
- Hou, Ching-Tsang; Patel, Ramesh N.; Laskin, Allen I.
- US Patent Document 4,241,184
Quantitative structure–activity relationships (QSARs) in toxicology: a historical perspective
journal, March 2003
- Schultz, T. Wayne; Cronin, Mark T. D.; Walker, John D.
- Journal of Molecular Structure: THEOCHEM, Vol. 622, Issue 1-2, p. 1-22
Quantitative Structure–Activity Relationship Methods: Perspectives on drug Discovery and Toxicology
journal, January 2003
- Perkins, Roger; Fang, Hong; Tong, Weida
- Environmental Toxicology and Chemistry, Vol. 22, Issue 8
Method and Apparatus for Detecting Chemical Binding
patent-application, January 2005
- Warner, Benjamin P.; Havrilla, George J.; Miller, Thomasin C.
- US Patent Application 10/621825; 20050011818
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
patent, September 1992
- Pirrung, Michael C.; Read, J. Leighton; Fodor, Stephen P. A.
- US Patent Document 5,143,854
Quantitation of antibody binding to cell surface antigens by X-ray fluorescence spectrometry
journal, March 1979
- Goldin, Eric M.; Corry, Peter M.; Granatek, Christine H.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 552, Issue 1, p. 120-128
A new sample substrate for imaging and correlating organic and trace metal composition in biological cells and tissues
journal, November 2006
- Miller, Lisa M.; Wang, Qi; Smith, Randy J.
- Analytical and Bioanalytical Chemistry, Vol. 387, Issue 5
Instrument access control system
patent-application, May 2004
- Hirsch, Thomas Steven
- US Patent Application 10/292666; 20040093526
Arrays of protein-capture agents and methods of use thereof
patent, December 2001
- Wagner, Peter; Nock, Steffen; Ault-Riche, Dana
- US Patent Document 6,329,209
X-Ray fluorescence testing of laminate structures
patent, March 1986
- Light, Glenn M.
- US Patent Document 4,577,337
Research in quantitative microscopic X-ray fluorescence analysis
journal, October 2004
- Lankosz, M.; Szczerbowska-Boruchowska, M.; Chwiej, J.
- Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 59, Issue 10-11
Binding of an inert, cationic osmium probe to walls of Bacillus subtilis
journal, March 1982
- Beveridge, T. J.; Jack, T.
- Journal of Bacteriology, Vol. 149, Issue 3
Toxicogenomics and drug discovery: will new technologies help us produce better drugs?
journal, January 2002
- Ulrich, Roger; Friend, Stephen H.
- Nature Reviews Drug Discovery, Vol. 1, Issue 1
Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity
patent, May 2002
- Sano, Takeshi; Glazer, Alexander N.; Cantor, Charles R.
- US Patent Document 6,391,590
Supported mesoporous carbon ultrafiltration membrane and process for making the same
patent, April 2004
- Strano, Michael S.; Foley, Henry C.; Agarwal, Hans
- US Patent Document 6,719,147