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Title: Drug development and manufacturing

X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
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Issue Date:
OSTI Identifier:
Warner; Benjamin P. LANL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2004 Jun 29
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
Country of Publication:
United States

Other works cited in this record:

Quantitation of antibody binding to cell surface antigens by X-ray fluorescence spectrometry
journal, March 1979
  • Goldin, Eric M.; Corry, Peter M.; Granatek, Christine H.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 552, Issue 1, p. 120-128
  • DOI: 10.1016/0005-2736(79)90251-7

Developing a Strategy for Activity-Based Detection of Enzymes in a Protein Microarray
journal, March 2003
  • Chen, Grace Y. J.; Uttamchandani, Mahesh; Zhu, Qing
  • ChemBioChem, Vol. 4, Issue 4, p. 336-339
  • DOI: 10.1002/cbic.200390054

Proteomics in drug discovery
journal, August 2002

Novel detection strategies for drug discovery
journal, September 2002

The theoretical derivation of fluorescent X-ray intensities from mixtures
journal, January 1955

Quantitative structure–activity relationships (QSARs) in toxicology: a historical perspective
journal, March 2003
  • Schultz, T. Wayne; Cronin, Mark T. D.; Walker, John D.
  • Journal of Molecular Structure: THEOCHEM, Vol. 622, Issue 1-2, p. 1-22
  • DOI: 10.1016/S0166-1280(02)00614-0

Evaluation of the protein concentration in enzymes via determination of sulfur by total reflection X-ray fluorescence spectrometry — limitations of the method
journal, November 2001
  • Mertens, M.; Rittmeyer, C.; Kolbesen, B. O.
  • Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 56, Issue 11, p. 2157-2164
  • DOI: 10.1016/S0584-8547(01)00294-4

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