Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers
Abstract
An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1484243
- Patent Number(s):
- 10081005
- Application Number:
- 14/777,973
- Assignee:
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- FG02-06ER64249; SC0001249
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Mar 26
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Moore, Melissa, Van Dam, R. Michael, Quinn, Kevin, Claggett, Shane, Herman, Henry, and Lazari, Mark. Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers. United States: N. p., 2018.
Web.
Moore, Melissa, Van Dam, R. Michael, Quinn, Kevin, Claggett, Shane, Herman, Henry, & Lazari, Mark. Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers. United States.
Moore, Melissa, Van Dam, R. Michael, Quinn, Kevin, Claggett, Shane, Herman, Henry, and Lazari, Mark. Tue .
"Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers". United States. https://www.osti.gov/servlets/purl/1484243.
@article{osti_1484243,
title = {Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers},
author = {Moore, Melissa and Van Dam, R. Michael and Quinn, Kevin and Claggett, Shane and Herman, Henry and Lazari, Mark},
abstractNote = {An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {9}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
journal, May 2010
- Anderson, Harry; Pillarsetty, NagaVaraKishore; Cantorias, Melchor
- Nuclear Medicine and Biology, Vol. 37, Issue 4, p. 439-442
Automated synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module
journal, February 2011
- Li, Zibo; Cai, Hancheng; Conti, Peter S.
- Nuclear Medicine and Biology, Vol. 38, Issue 2, p. 201-206
Modular Cassette Synthesis Unit
patent-application, January 2013
- Klausing, Thomas A.; Stroup, Jeffrey T.; Kelley, Brian C.
- US Patent Application 13/550026; 20130020727
Abstract 5746: ARC-P HS+: A versatile radiosynthesizer for the production of PET tracers
conference, November 2014
- Moore, Melissa D.; Quinn, Kevin; Claggett, Shane
- Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL, Cancer Chemistry
Apparatus and Method for Producing Radiopharmaceuticals
patent-application, November 2006
- Kiselev, Maxim Y.; Vanto, Tomas
- US Patent Application 11/380914; 20060245980
The improved syntheses of 5-substituted 2′-[18F]fluoro-2′-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy
journal, July 2011
- Cai, Hancheng; Li, Zibo; Conti, Peter S.
- Nuclear Medicine and Biology, Vol. 38, Issue 5, p. 659-666
Method and Device for Manufacturing of Radiopharmaceuticals
patent-application, May 2012
- Kiselev, Maxim
- US Patent Application 12/982499; 20120108858
Synthesis of [18F]-labeled 2?-deoxy-2?-fluoro-5-methyl-1-?-D-arabinofuranosyluracil ([18F]-FMAU)
journal, January 2002
- Alauddin, Mian M.; Conti, Peter S.; Fissekis, John D.
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 45, Issue 7
Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
journal, January 2003
- Alauddin, Mian M.; Fissekis, John D.; Conti, Peter S.
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, Issue 9, p. 805-814
Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences
journal, October 2010
- Coenen, H. H.; Elsinga, P. H.; Iwata, R.
- Nuclear Medicine and Biology, Vol. 37, Issue 7, p. 727-740
Semiautomated Radiosynthesis and Biological Evaluation of [18F]FEAU: A Novel PET Imaging Agent for HSV1-tk/sr39tk Reporter Gene Expression
journal, December 2007
- Chin, Frederick T.; Namavari, Mohammed; Levi, Jelena
- Molecular Imaging and Biology, Vol. 10, Issue 2
Emerging Technologies for Decentralized Production of PET Tracers
book, February 2012
- Keng, Pei Yuin; Esterby, Melissa; van Dam, R. Michael
- Positron Emission Tomography - Current Clinical and Research Aspects
A fully automated synthesis of [ 18 F]-FEAU and [ 18 F]-FMAU using a novel dual reactor radiosynthesis module
journal, November 2009
- Paolillo, Vincenzo; Riese, Stefan; Gelovani, Juri G.
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 52, Issue 13
Automation for Optimised Production of Fluorine-18-Labelled Radiopharmaceuticals
journal, July 2010
- I. Sachinidis, John; Poniger, Stan; J. Tochon-Danguy, Henri
- Current Radiopharmaceuticalse, Vol. 3, Issue 3