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Title: Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers

An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1484243
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA) CHO
Patent Number(s):
10,081,005
Application Number:
14/777,973
Contract Number:
FG02-06ER64249; SC0001249
Resource Relation:
Patent File Date: 2014 Mar 26
Research Org:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English

Works referenced in this record:

Improved synthesis of 2?-deoxy-2?-[18F]-fluoro-1-?-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
journal, May 2010
  • Anderson, Harry; Pillarsetty, NagaVaraKishore; Cantorias, Melchor
  • Nuclear Medicine and Biology, Vol. 37, Issue 4, p. 439-442
  • DOI: 10.1016/j.nucmedbio.2010.01.003

Automated synthesis of 2?-deoxy-2?-[18F]fluoro-5-methyl-1-?-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module
journal, February 2011