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Title: Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride

Abstract

The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.

Inventors:
;
Issue Date:
Research Org.:
Washington Univ., St. Louis, MO (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1892591
Patent Number(s):
11242314
Application Number:
15/403,954
Assignee:
Washington University (Chesterfield, MO)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
DOE Contract Number:  
CA025836; SC0008432
Resource Type:
Patent
Resource Relation:
Patent File Date: 01/11/2017
Country of Publication:
United States
Language:
English

Citation Formats

Zhou, Dong, and Chu, Wenhua. Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride. United States: N. p., 2022. Web.
Zhou, Dong, & Chu, Wenhua. Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride. United States.
Zhou, Dong, and Chu, Wenhua. Tue . "Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride". United States. https://www.osti.gov/servlets/purl/1892591.
@article{osti_1892591,
title = {Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride},
author = {Zhou, Dong and Chu, Wenhua},
abstractNote = {The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {2}
}

Works referenced in this record:

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Method for Rapid Preparation of Suitable [18F] Fluoride for Nucleophilic [18F] Fluorination
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System, Device and Method for Preparing Tracers and Transferring Materials During Radiosynthesis
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Sulfonyl Fluoride-Based Prosthetic Compounds as Potential18F Labelling Agents
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