Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
Abstract
The production and use of semiconducting nanopost arrays made by nanofabrication is described herein. These nanopost arrays (NAPA) provide improved laser ionization yields and controllable fragmentation with switching or modulation capabilities for mass spectrometric detection and identification of samples deposited on them.
- Inventors:
- Issue Date:
- Research Org.:
- George Washington Univ., Washington, DC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1331181
- Patent Number(s):
- 9490113
- Application Number:
- 12/755,769
- Assignee:
- The George Washington University (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- FG02-01ER15129
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Apr 07
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Vertes, Akos, Walker, Bennett N., Stolee, Jessica A., and Retterer, Scott T. Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry. United States: N. p., 2016.
Web.
Vertes, Akos, Walker, Bennett N., Stolee, Jessica A., & Retterer, Scott T. Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry. United States.
Vertes, Akos, Walker, Bennett N., Stolee, Jessica A., and Retterer, Scott T. Tue .
"Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry". United States. https://www.osti.gov/servlets/purl/1331181.
@article{osti_1331181,
title = {Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry},
author = {Vertes, Akos and Walker, Bennett N. and Stolee, Jessica A. and Retterer, Scott T.},
abstractNote = {The production and use of semiconducting nanopost arrays made by nanofabrication is described herein. These nanopost arrays (NAPA) provide improved laser ionization yields and controllable fragmentation with switching or modulation capabilities for mass spectrometric detection and identification of samples deposited on them.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 08 00:00:00 EST 2016},
month = {Tue Nov 08 00:00:00 EST 2016}
}
Works referenced in this record:
Desorption/ionization of analytes from porous light-absorbing semiconductor
patent, September 2001
- Siuzdak, Gary; Buriak, Jillian; Wei, Jing
- US Patent Document 6,288,390
Deposited thin films and their use in detection, attachment and bio-medical applications
patent, September 2004
- Fonash, Stephen J.; Bae, Sanghoon; Hayes, Daniel J.
- US Patent Document 6,794,196
Functionalized silicon surfaces
patent, January 2005
- Buriak, Jillian; Stewart, Michael P.; Robins, Edward
- US Patent Document 6,846,681
Method for producing a three-dimensional macro-molecular structure
patent, April 2005
- Schlaf, Rudiger; Kohlscheen, Joern; Braunagel, Chris
- US Patent Document 6,881,950
Sample desorption/ionization from mesoporous silica
patent, October 2005
- Iyer, Srinivas; Dattelbaum, Andrew M.
- US Patent Document 6,958,480
Reduction of matrix interference for MALDI mass spectrometry analysis
patent, February 2006
- Donegan, Michael; Tomlinson, Andrew J.; Nair, Perumanath H.
- US Patent Document 6,995,363
Photocrosslinked hydrogel blend surface coatings
patent, May 2006
- Huang, Wenxi; Um, Pil-Je
- US Patent Document 7,045,366
Dynamically controllable biological/chemical detectors having nanostructured surfaces
patent, May 2006
- Arney, Susanne; Kroupenkine, Timofei Nikita; Lyons, Alan Michael
- US Patent Document 7,048,889
Probe for mass spectrometry
patent, June 2006
- Koopman, Jens-Oliver; Blackburn, Jonathan Michael
- US Patent Document 7,057,165
Retentate chromatography and protein chip arrays with applications in biology and medicine
patent, September 2006
- Hutchens, T. William; Yip, Tai-Tung
- US Patent Document 7,112,453
Manufacture of silicon-based devices having disordered sulfur-doped surface layers
patent, April 2008
- Carey, James E.; Mazur, Eric
- US Patent Document 7,354,792
Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis
patent, June 2008
- Haase, Andreas; Kayser, Markus; Höhndorf, Jens
- US Patent Document 7,385,192
Femtosecond laser-induced formation of submicrometer spikes on a semiconductor substrate
patent, October 2008
- Mazur, Eric; Shen, Mengyan
- US Patent Document 7,442,629
Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
patent, February 2012
- Vertes, Akos; Walker, Bennett N.
- US Patent Document 8,110,796
Sample target used in mass spectrometry, method for producing the same, and mass spectrometer using the sample target
patent, August 2012
- Okuno, Shoji; Wada, Yoshinao; Yanagishita, Takashi
- US Patent Document 8,237,114
Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
patent, September 2013
- Vertes, Akos; Walker, Bennett N.
- US Patent Document 8,530,833
Method and apparatus for feedback controlled electrospray
patent-application, December 2002
- Valaskovic, Gary A.; Lee, Mike S.
- US Patent Application 10/154767; 20020190203
Multidimensional Liquid Chromatography/Spectrometry
patent-application, July 2006
- Siuzdak, Gary; Shen, Zhouxin
- US Patent Application 11/036160; 20060157647
Methods, Compositions and Devices for Performing Ionization Desorption of Silicon Derivatives
patent-application, July 2006
- Siuzdak, Gary; Go, Eden; Shen, Zhouxin
- US Patent Application 11/288590; 20060157648
Nanofiber Surfaces for Use in Enhanced Surface Area Applications
patent-application, July 2006
- Dubrow, Robert; Daniels, Robert Hugh; Parce, J. Wallace
- US Patent Application 10/840794; 20060159916
Methods and apparatus for porous membrane electrospray and multiplexed coupling of microfluidic systems with mass spectrometry
patent-application, August 2006
- DeVoe, Donald L.; Wang, Yingxin; Lee, Cheng S.
- US Patent Document 11/242842; 20060192107
Laser Desorption Ionization and Peptide Sequencing on Laser Induced Silicon Microcolumn Arrays
patent-application, December 2009
- Vertes, Akos; Chen, Yong
- US Patent Application 11/674671; 20090321626
Assessment of laser-induced thermal load on silicon nanostructures based on ion desorption yields
journal, July 2010
- Walker, Bennett N.; Stolee, Jessica A.; Pickel, Deanna L.
- Applied Physics A, Vol. 101, Issue 3
Nanophotonic Ion Production from Silicon Microcolumn Arrays
journal, January 2009
- Walker, Bennett N.; Razunguzwa, Trust; Powell, Matthew
- Angewandte Chemie International Edition, Vol. 48, Issue 9, p. 1669-1672
High Sensitivity and Analyte Capture with Desorption/Ionization Mass Spectrometry on Silylated Porous Silicon
journal, August 2004
- Trauger, Sunia A.; Go, Eden P.; Shen, Zhouxin
- Analytical Chemistry, Vol. 76, Issue 15
Surface nanostructuring of silicon
journal, July 2003
- Pedraza, A. J.; Fowlkes, J. D.; Guan, Y. -F.
- Applied Physics A, Vol. 77, Issue 2
Surfactant-Enhanced Desorption/Ionization on Silicon Mass Spectrometry
journal, January 2006
- Nordström, Anders; Apon, Junefredo V.; Uritboonthai, Wilasinee
- Analytical Chemistry, Vol. 78, Issue 1
Matrix-assisted laser desorption/ionization of peptides on AnchorChip™ targets with α-cyano-4-hydroxycinnamic acid and nitrocellulose as matrix
journal, January 2005
- Wu, Yu-Ching; Hsieh, Cheng-Hsilin; Tam, Ming F.
- Rapid Communications in Mass Spectrometry, Vol. 20, Issue 2
Internal Energy Transfer in Laser Desorption/Ionization from Silicon Nanowires
journal, July 2006
- Luo, Guanghong; Chen, Yong; Daniels, Hugh
- The Journal of Physical Chemistry B, Vol. 110, Issue 27
Surface Modification and Laser Pulse Length Effects on Internal Energy Transfer in DIOS
journal, December 2005
- Luo, Guanghong; Chen, Yong; Siuzdak, Gary
- The Journal of Physical Chemistry B, Vol. 109, Issue 51
Growth and application of highly ordered array of vertical nanoposts
journal, January 2006
- Kuo, Teng-Fang; Xu, Jimmy
- Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, Vol. 24, Issue 4
Femtosecond laser-induced formation of spikes on silicon
journal, April 2000
- Her, T. -H.; Finlay, R. J.; Wu, C.
- Applied Physics A: Materials Science & Processing, Vol. 70, Issue 4
Desorption/ionization mass spectrometry on array of silicon microtips
journal, January 2005
- Gorecka-Drzazga, Anna; Dziuban, Jan; Drzazga, Wlodzimierz
- Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, Vol. 23, Issue 2
Desorption/Ionization on Silicon Time-of-Flight/Time-of-Flight Mass Spectrometry
journal, May 2003
- Go, Eden P.; Prenni, Jessica E.; Wei, Jing
- Analytical Chemistry, Vol. 75, Issue 10
Comparison of structure and properties of femtosecond and nanosecond laser-structured silicon
journal, March 2004
- Crouch, C. H.; Carey, J. E.; Warrender, J. M.
- Applied Physics Letters, Vol. 84, Issue 11, p. 1850-1852
Adjustable Fragmentation in Laser Desorption/Ionization from Laser-Induced Silicon Microcolumn Arrays
journal, August 2006
- Chen, Yong; Vertes, Akos
- Analytical Chemistry, Vol. 78, Issue 16
Tailoring Nanoparticle Surface Chemistry to Enhance Laser Desorption Ionization of Peptides and Proteins
journal, October 2007
- Castellana, Edward T.; Russell, David H.
- Nano Letters, Vol. 7, Issue 10
Improved broadband and quasi-omnidirectional anti-reflection properties with biomimetic silicon nanostructures
journal, December 2007
- Huang, Yi-Fan; Chattopadhyay, Surojit; Jen, Yi-Jun
- Nature Nanotechnology, Vol. 2, Issue 12, p. 770-774
Near-field fluorescence imaging by localized field enhancement near a sharp probe tip
journal, April 2000
- Hamann, Hendrik F.; Gallagher, Alan; Nesbitt, David J.
- Applied Physics Letters, Vol. 76, Issue 14
Polarization sensitivity of optical resonant dipole antennas
journal, January 2008
- Fischer, Holger; Martin, Olivier J. F.
- Journal of the European Optical Society: Rapid Publications, Vol. 3
Single Quantum Dot Coupled to a Scanning Optical Antenna: A Tunable Superemitter
journal, June 2005
- Farahani, J. N.; Pohl, D. W.; Eisler, H. -J.
- Physical Review Letters, Vol. 95, Issue 1
Plasmonic laser antenna
journal, August 2006
- Cubukcu, Ertugrul; Kort, Eric A.; Crozier, Kenneth B.
- Applied Physics Letters, Vol. 89, Issue 9
Optical antennas: Resonators for local field enhancement
journal, October 2003
- Crozier, K. B.; Sundaramurthy, A.; Kino, G. S.
- Journal of Applied Physics, Vol. 94, Issue 7
Ballistic-Diffusive Heat-Conduction Equations
journal, March 2001
- Chen, Gang
- Physical Review Letters, Vol. 86, Issue 11
Field enhancement in apertureless near-field scanning optical microscopy
journal, January 2001
- Bohn, John L.; Nesbitt, D. J.; Gallagher, A.
- Journal of the Optical Society of America A, Vol. 18, Issue 12
Enhancement and Quenching of Single-Molecule Fluorescence
journal, March 2006
- Anger, Pascal; Bharadwaj, Palash; Novotny, Lukas
- Physical Review Letters, Vol. 96, Issue 11, Article No. 113002
Interaction of powerful laser radiation with the surfaces of semiconductors and metals: nonlinear optical effects and nonlinear optical diagnostics
journal, December 1985
- Akhmanov, S. A.; Emel'yanov, Vladimir I.; Koroteev, Nikolai I.
- Soviet Physics Uspekhi, Vol. 28, Issue 12
Contributions of mass spectrometry to peptide and protein structure
journal, October 1988
- Biemann, Klaus
- Biological Mass Spectrometry, Vol. 16, Issue 1-12, p. 99-111
Silicon electron emitters fabricated by ultraviolet laser pulses
journal, February 2006
- Zorba, V.; Tzanetakis, P.; Fotakis, C.
- Applied Physics Letters, Vol. 88, Issue 8
Correlation of Kinetic Energy Losses in High-Energy Collision-Induced Dissociation with Observed Peptide Product Ions
journal, January 1996
- Vachet, Richard W.; Winders, Andrew D.; Glish, Gary L.
- Analytical Chemistry, Vol. 68, Issue 3
Optical antennas direct single-molecule emission
journal, March 2008
- Taminiau, T. H.; Stefani, F. D.; Segerink, F. B.
- Nature Photonics, Vol. 2, Issue 4
High-Energy Fragmentation in Nanophotonic Ion Production by Laser-Induced Silicon Microcolumn Arrays
journal, October 2009
- Stolee, Jessica A.; Chen, Yong; Vertes, Akos
- The Journal of Physical Chemistry C, Vol. 114, Issue 12
Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
journal, April 2001
- Stöckle, Raoul; Setz, Patrick; Deckert, Volker
- Analytical Chemistry, Vol. 73, Issue 7
Near-Field Fluorescence Microscopy Based on Two-Photon Excitation with Metal Tips
journal, May 1999
- Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney
- Physical Review Letters, Vol. 82, Issue 20
Femtosecond laser near-field ablation from gold nanoparticles
journal, December 2005
- Plech, Anton; Kotaidis, Vassilios; Lorenc, Maciej
- Nature Physics, Vol. 2, Issue 1
Laser Desorption-Atmospheric Pressure Chemical Ionization Mass Spectrometry for the Analysis of Peptides from Aqueous Solutions
journal, November 2002
- Coon, Joshua J.; Harrison, W. W.
- Analytical Chemistry, Vol. 74, Issue 21
New dimension in nano-imaging: breaking through the diffraction limit with scanning near-field optical microscopy
journal, November 2004
- Rasmussen, Akiko; Deckert, Volker
- Analytical and Bioanalytical Chemistry, Vol. 381, Issue 1
Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry
journal, May 2006
- Huang, Min-Zong; Hsu, Hsiu-Jung; Lee, Jen-Yih
- Journal of Proteome Research, Vol. 5, Issue 5
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
journal, October 2004
- Takats, Z.
- Science, Vol. 306, Issue 5695, p. 471-473
Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
journal, April 2005
- Cody, Robert B.; Laramée, James A.; Durst, H. Dupont
- Analytical Chemistry, Vol. 77, Issue 8, p. 2297-2302
Desorption−Ionization Mass Spectrometry Using Deposited Nanostructured Silicon Films
journal, March 2001
- Cuiffi, Joseph D.; Hayes, Daniel J.; Fonash, Stephen J.
- Analytical Chemistry, Vol. 73, Issue 6
Matrix-Free Laser Desorption/Ionization Mass Spectrometry on Silicon Nanowire Arrays Prepared by Chemical Etching of Crystalline Silicon
journal, January 2010
- Piret, Gaëlle; Drobecq, Hervé; Coffinier, Yannick
- Langmuir, Vol. 26, Issue 2