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Title: Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays

Abstract

The present invention provides a method of producing a laser-patterned silicon surface, especially silicon wafers for use in laser desorption ionization (LDI-MS) (including MALDI-MS and SELDI-MS), devices containing the same, and methods of testing samples employing the same. The surface is prepared by subjecting a silicon substrate to multiple laser shots from a high-power picosecond or femtosecond laser while in a processing environment, e.g., underwater, and generates a remarkable homogenous microcolumn array capable of providing an improved substrate for LDI-MS.

Inventors:
 [1];  [2]
  1. Reston, VA
  2. San Diego, CA
Issue Date:
Research Org.:
George Washington Univ., Washington, DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1034108
Patent Number(s):
8084734
Application Number:
11/674,671
Assignee:
The George Washington University (Washington, DC)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B29 - WORKING OF PLASTICS B29C - SHAPING OR JOINING OF PLASTICS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
FG02-01ER15129
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Vertes, Akos, and Chen, Yong. Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays. United States: N. p., 2011. Web.
Vertes, Akos, & Chen, Yong. Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays. United States.
Vertes, Akos, and Chen, Yong. Tue . "Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays". United States. https://www.osti.gov/servlets/purl/1034108.
@article{osti_1034108,
title = {Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays},
author = {Vertes, Akos and Chen, Yong},
abstractNote = {The present invention provides a method of producing a laser-patterned silicon surface, especially silicon wafers for use in laser desorption ionization (LDI-MS) (including MALDI-MS and SELDI-MS), devices containing the same, and methods of testing samples employing the same. The surface is prepared by subjecting a silicon substrate to multiple laser shots from a high-power picosecond or femtosecond laser while in a processing environment, e.g., underwater, and generates a remarkable homogenous microcolumn array capable of providing an improved substrate for LDI-MS.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {12}
}

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Works referenced in this record:

Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
journal, April 2001


High Sensitivity and Analyte Capture with Desorption/Ionization Mass Spectrometry on Silylated Porous Silicon
journal, August 2004


Desorption−Ionization Mass Spectrometry Using Deposited Nanostructured Silicon Films
journal, March 2001


Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
journal, April 2005


Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry
journal, May 2006


New dimension in nano-imaging: breaking through the diffraction limit with scanning near-field optical microscopy
journal, November 2004