Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Ehst, David A.; Willit, James L.

Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Inventors:: Ehst, David A.; Willit, James L.

Issue Date:: 2016-04-12

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1248479

Patent Number(s):: 9312037

Application Number:: 13/399,082

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Classifications (CPCs):: H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE

G - PHYSICS G21 - NUCLEAR PHYSICS G21K - TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR

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H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
H05H6/00 - Targets for producing nuclear reactions

G - PHYSICS G21 - NUCLEAR PHYSICS G21K - TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR
G21K5/08 - Holders for targets or for other objects to be irradiated

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/12 - by electromagnetic irradiation, e.g. with gamma or X-rays
G21G2001/0094 - {Other isotopes not provided for in the groups listed above}
G21G1/001 - {Recovery of specific isotopes from irradiated targets}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D7/00 - Sublimation

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DOE Contract Number:: AC02-06CH11357

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Feb 17

Country of Publication:: United States

Language:: English

Subject:: 07 ISOTOPE AND RADIATION SOURCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Ehst, David A., and Willit, James L. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications.  United States: N. p., 2016. 
        Web.

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                    Ehst, David A., & Willit, James L. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications.  United States.

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                    Ehst, David A., and Willit, James L. Tue .  
        "Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications".  United States.  https://www.osti.gov/servlets/purl/1248479.

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@article{osti_1248479,

  title        = {Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications},

  author       = {Ehst, David A. and Willit, James L.},

  abstractNote = {The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {4}

}

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Works referenced in this record:

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36
https://doi.org/10.1016/0883-2889(86)90192-9

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions
journal, April 2004

Jal, P.
Talanta, Vol. 62, Issue 5
https://doi.org/10.1016/j.talanta.2003.10.028

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

Marceau, N.; Kruck, T. P. A.; McConnell, D. B.
The International Journal of Applied Radiation and Isotopes, Vol. 21, Issue 11, p. 667-669
https://doi.org/10.1016/0020-708X(70)90121-3

The Preparation of High Specific Activity Copper 64
journal, January 1964

Fritze, K.
Radiochimica Acta, Vol. 3, Issue 3
https://doi.org/10.1524/ract.1964.3.3.166

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The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.
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Similar Records

Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

Citation Formats

Production of no-carrier added 67Cu journal, January 1986

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions journal, April 2004

The production of copper 67 from natural zinc using a linear accelerator journal, November 1970

The Preparation of High Specific Activity Copper 64 journal, January 1964

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions
journal, April 2004

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

The Preparation of High Specific Activity Copper 64
journal, January 1964