Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Ehst, David A.; Willit, James L.

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Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Inventors:: Ehst, David A.; Willit, James L.

Issue Date:: Tue Apr 12 00:00:00 EDT 2016

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1248479

Patent Number(s):: 9312037

Application Number:: 13/399,082

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

Show more

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D7/00 - Sublimation

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/001 - {Recovery of specific isotopes from irradiated targets}
G21G1/12 - by electromagnetic irradiation, e.g. with gamma or X-rays
G21G2001/0094 - {Other isotopes not provided for in the groups listed above}

G - PHYSICS G21 - NUCLEAR PHYSICS G21K - TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR
G21K5/08 - Holders for targets or for other objects to be irradiated

H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
H05H6/00 - Targets for producing nuclear reactions

Show less

DOE Contract Number:: AC02-06CH11357

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Feb 17

Country of Publication:: United States

Language:: English

Subject:: 07 ISOTOPE AND RADIATION SOURCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Ehst, David A., and Willit, James L. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications.  United States: N. p., 2016. 
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                    Ehst, David A., & Willit, James L. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications.  United States.

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                    Ehst, David A., and Willit, James L. Tue .  
        "Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications".  United States.  https://www.osti.gov/servlets/purl/1248479.

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@article{osti_1248479,

  title        = {Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications},

  author       = {Ehst, David A. and Willit, James L.},

  abstractNote = {The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 12 00:00:00 EDT 2016},

  month        = {Tue Apr 12 00:00:00 EDT 2016}

}

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Works referenced in this record:

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36
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Marceau, N.; Kruck, T. P. A.; McConnell, D. B.
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Fritze, K.
Radiochimica Acta, Vol. 3, Issue 3
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Operhall, Theodore
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Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications
patent-application, February 2010

Ehst, David A.; Bowers, Delbert L.
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Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Patent Ehst, David A.; Willit, James L.

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.
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The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g., chemical and/or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc (e.g., at about 500-700° C. under reduced pressure) to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means (i.e., dissolution in acid, followed by ion exchange).
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Similar Records

Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

Citation Formats

Production of no-carrier added 67Cu journal, January 1986

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions journal, April 2004

The production of copper 67 from natural zinc using a linear accelerator journal, November 1970

The Preparation of High Specific Activity Copper 64 journal, January 1964

Process of Casting Titanium and Related Metal and Alloys patent, September 1957

Process for Separating Iodine-132 from Fission Products patent, June 1960

Melting and Casting of Titanium patent, December 1968

Separation Metals patent, December 1968

Radioisotope Fuel Capsule patent, November 1971

Radioactive waste material melter apparatus patent, April 1990

Polymer beads containing an immobilized extractant for sorbing metals from solution patent, January 1994

Glass gob drop guide funnel assembly patent, March 1995

Extrusion-resistant seal assembly patent, June 1995

Method of producing molybdenum-99 patent, July 1998

Production of radioisotopes with a high specific activity by isotopic conversion patent, September 1999

Production of radioisotopes with a high specific activity by isotopic conversion patent, March 2001

Production of high specific activity copper -67 patent, December 2002

Devices and methods for melting materials patent, October 2007

Sublimation purifying method and apparatus patent-application, February 2003

Devices and methods for melting materials patent-application, September 2014

Process for extraction of metals from ores or industrial materials patent-application, February 2006

Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications patent-application, February 2010

Nanostructured Target for Isotope Production patent-application, September 2011

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions
journal, April 2004

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

The Preparation of High Specific Activity Copper 64
journal, January 1964

Process of Casting Titanium and Related Metal and Alloys
patent, September 1957

Process for Separating Iodine-132 from Fission Products
patent, June 1960

Melting and Casting of Titanium
patent, December 1968

Separation Metals
patent, December 1968

Radioisotope Fuel Capsule
patent, November 1971

Radioactive waste material melter apparatus
patent, April 1990

Polymer beads containing an immobilized extractant for sorbing metals from solution
patent, January 1994

Glass gob drop guide funnel assembly
patent, March 1995

Extrusion-resistant seal assembly
patent, June 1995

Method of producing molybdenum-99
patent, July 1998

Production of radioisotopes with a high specific activity by isotopic conversion
patent, September 1999

Production of radioisotopes with a high specific activity by isotopic conversion
patent, March 2001

Production of high specific activity copper -67
patent, December 2002

Devices and methods for melting materials
patent, October 2007

Sublimation purifying method and apparatus
patent-application, February 2003

Devices and methods for melting materials
patent-application, September 2014

Process for extraction of metals from ores or industrial materials
patent-application, February 2006

Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications
patent-application, February 2010

Nanostructured Target for Isotope Production
patent-application, September 2011