Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Inventors:: Ehst, David A.; Willit, James L.

Issue Date:: 2016-04-12

OSTI Identifier:: 1248479

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL) ANL

Patent Number(s):: 9,312,037

Application Number:: 13/399,082

Contract Number:: AC02-06CH11357

Resource Relation:: Patent File Date: 2012 Feb 17

Research Org:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 07 ISOTOPE AND RADIATION SOURCES; 60 APPLIED LIFE SCIENCES

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Other works cited in this record:

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36
DOI: 10.1016/0883-2889(86)90192-9

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

Marceau, N.; Kruck, T. P. A.; McConnell, D. B.
The International Journal of Applied Radiation and Isotopes, Vol. 21, Issue 11, p. 667-669
DOI: 10.1016/0020-708X(70)90121-3

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