Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Ehst, David A.; Willit, James L.

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Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Inventors:: Ehst, David A.; Willit, James L.

Issue Date:: Tue Nov 20 00:00:00 EST 2018

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1495041

Patent Number(s):: 10134497

Application Number:: 15/087,111

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

Show more

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D7/00 - Sublimation

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/001 - {Recovery of specific isotopes from irradiated targets}
G21G1/12 - by electromagnetic irradiation, e.g. with gamma or X-rays
G21G2001/0094 - {Other isotopes not provided for in the groups listed above}

G - PHYSICS G21 - NUCLEAR PHYSICS G21K - TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR
G21K5/08 - Holders for targets or for other objects to be irradiated

H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
H05H6/00 - Targets for producing nuclear reactions

Show less

DOE Contract Number:: AC02-06CH11357

Resource Type:: Patent

Resource Relation:: Patent File Date: 2016 Mar 31

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats


                    Ehst, David A., and Willit, James L. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications.  United States: N. p., 2018. 
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                    Ehst, David A., & Willit, James L. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications.  United States.

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                    Ehst, David A., and Willit, James L. Tue .  
        "Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications".  United States.  https://www.osti.gov/servlets/purl/1495041.

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@article{osti_1495041,

  title        = {Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications},

  author       = {Ehst, David A. and Willit, James L.},

  abstractNote = {The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Nov 20 00:00:00 EST 2018},

  month        = {Tue Nov 20 00:00:00 EST 2018}

}

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Works referenced in this record:

Process for Separating Iodine-132 from Fission Products
patent, June 1960

Greene, Margaret W.; Samos, George; Tucker, Walter D.
US Patent Document 2,942,943
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/2942943

Devices and methods for melting materials
patent, October 2007

Yamada, Fujio
US Patent Document 7,284,592
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7284592

Photonuclear Production of ⁶⁷Cu from ZnO Targets
journal, December 1986

Polak, P.; Geradts, J.; Vlist, R. Van Der
ract, Vol. 40, Issue 4
https://doi.org/10.1524/ract.1986.40.4.169

Devices and methods for melting materials
patent-application, September 2014

Yamada, Fujio
US Patent Application 10/793878; 20040168787
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040168787

Method of producing molybdenum-99
patent, July 1998

Lidsky, Lawrence M.; Lanza, Richard C.
US Patent Document 5,784,423
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5784423

Preparation of carrier-free 67Cu by the 68Zn(γ,p) reaction
journal, December 1978

Yagi, Masuo; Kondo, Kenjiro
The International Journal of Applied Radiation and Isotopes, Vol. 29, Issue 12
https://doi.org/10.1016/0020-708X(78)90127-8

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36
https://doi.org/10.1016/0883-2889(86)90192-9

Separation Metals
patent, December 1968

Hardy, Clarence James
US Patent Document 3,419,348
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/3419348

Nanostructured Target for Isotope Production
patent-application, September 2011

Stora, Thierry; Fernandes Da Visitacao, Sandrina; Mathot, Serge
US Patent Application 13/120709; 20110235766
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110235766

Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications
patent-application, February 2010

Ehst, David A.; Bowers, Delbert L.
US Patent Application 12/462099; 20100028234
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100028234

Radioactive waste material melter apparatus
patent, April 1990

Newman, Darrell F.; Ross, Wayne A.
US Patent Document 4,919,190
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4919190

Glass gob drop guide funnel assembly
patent, March 1995

Sweetland, James E.
US Patent Document 5,394,910
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5394910

Extrusion-resistant seal assembly
patent, June 1995

Hopkins, Ronald J.
US Patent Document 5,426,676
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5426676

The Preparation of High Specific Activity Copper 64
journal, January 1964

Fritze, K.
Radiochimica Acta, Vol. 3, Issue 3
https://doi.org/10.1524/ract.1964.3.3.166

Radioisotope Fuel Capsule
patent, November 1971

Princiotta, Frank T.; Barr, Harold N.
US Patent Document 3,621,261
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/3621261

Production of radioisotopes with a high specific activity by isotopic conversion
patent, March 2001

Lidsky, Lawrence M.; Lanza, Richard C.
US Patent Document 6,208,704
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6208704

The production, separation, and use of 67Cu for radioimmunotherapy: A review
journal, October 2012

Smith, Nicholas A.; Bowers, Delbert L.; Ehst, David A.
Applied Radiation and Isotopes, Vol. 70, Issue 10
https://doi.org/10.1016/j.apradiso.2012.07.009

Production of high specific activity copper -67
patent, December 2002

Jamriska, Sr., David J.; Taylor, Wayne A.; Ott, Martin A.
US Patent Document 6,490,330
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6490330

Polymer beads containing an immobilized extractant for sorbing metals from solution
patent, January 1994

Jeffers, Thomas H.; Seidel, Don C.
US Patent Document 5,279,745
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5279745

Process for extraction of metals from ores or industrial materials
patent-application, February 2006

Holgersen, James D.
US Patent Application 11/252843; 20060037438
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060037438

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

Marceau, N.; Kruck, T. P. A.; McConnell, D. B.
The International Journal of Applied Radiation and Isotopes, Vol. 21, Issue 11, p. 667-669
https://doi.org/10.1016/0020-708X(70)90121-3

Melting and Casting of Titanium
patent, December 1968

Rosenberg, Robert A.
US Patent Document 3,417,808
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/3417808

Production of radioisotopes with a high specific activity by isotopic conversion
patent, September 1999

Lidsky, Lawrence M.; Lanza, Richard C.
US Patent Document 5,949,836
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5949836

Process of Casting Titanium and Related Metal and Alloys
patent, September 1957

Operhall, Theodore
US Patent Document 2,806,271
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/2806271

Sublimation purifying method and apparatus
patent-application, February 2003

Soeda, Mahito; Hotta, Shuhei; Ishii, Kazuo
US Patent Application 10/239064; 20030030193
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030030193

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions
journal, April 2004

Jal, P.
Talanta, Vol. 62, Issue 5
https://doi.org/10.1016/j.talanta.2003.10.028

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Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

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The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.
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Similar Records

Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

Citation Formats

Process for Separating Iodine-132 from Fission Products patent, June 1960

Devices and methods for melting materials patent, October 2007

Photonuclear Production of 67Cu from ZnO Targets journal, December 1986

Devices and methods for melting materials patent-application, September 2014

Method of producing molybdenum-99 patent, July 1998

Preparation of carrier-free 67Cu by the 68Zn(γ,p) reaction journal, December 1978

Production of no-carrier added 67Cu journal, January 1986

Separation Metals patent, December 1968

Nanostructured Target for Isotope Production patent-application, September 2011

Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications patent-application, February 2010

Radioactive waste material melter apparatus patent, April 1990

Glass gob drop guide funnel assembly patent, March 1995

Extrusion-resistant seal assembly patent, June 1995

The Preparation of High Specific Activity Copper 64 journal, January 1964

Radioisotope Fuel Capsule patent, November 1971

Production of radioisotopes with a high specific activity by isotopic conversion patent, March 2001

The production, separation, and use of 67Cu for radioimmunotherapy: A review journal, October 2012

Production of high specific activity copper -67 patent, December 2002

Polymer beads containing an immobilized extractant for sorbing metals from solution patent, January 1994

Process for extraction of metals from ores or industrial materials patent-application, February 2006

The production of copper 67 from natural zinc using a linear accelerator journal, November 1970

Melting and Casting of Titanium patent, December 1968

Production of radioisotopes with a high specific activity by isotopic conversion patent, September 1999

Process of Casting Titanium and Related Metal and Alloys patent, September 1957

Sublimation purifying method and apparatus patent-application, February 2003

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions journal, April 2004

Process for Separating Iodine-132 from Fission Products
patent, June 1960

Devices and methods for melting materials
patent, October 2007

Photonuclear Production of ⁶⁷Cu from ZnO Targets
journal, December 1986

Devices and methods for melting materials
patent-application, September 2014

Method of producing molybdenum-99
patent, July 1998

Preparation of carrier-free 67Cu by the 68Zn(γ,p) reaction
journal, December 1978

Production of no-carrier added ⁶⁷Cu
journal, January 1986

Separation Metals
patent, December 1968

Nanostructured Target for Isotope Production
patent-application, September 2011

Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications
patent-application, February 2010

Radioactive waste material melter apparatus
patent, April 1990

Glass gob drop guide funnel assembly
patent, March 1995

Extrusion-resistant seal assembly
patent, June 1995

The Preparation of High Specific Activity Copper 64
journal, January 1964

Radioisotope Fuel Capsule
patent, November 1971

Production of radioisotopes with a high specific activity by isotopic conversion
patent, March 2001

The production, separation, and use of 67Cu for radioimmunotherapy: A review
journal, October 2012

Production of high specific activity copper -67
patent, December 2002

Polymer beads containing an immobilized extractant for sorbing metals from solution
patent, January 1994

Process for extraction of metals from ores or industrial materials
patent-application, February 2006

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

Melting and Casting of Titanium
patent, December 1968

Production of radioisotopes with a high specific activity by isotopic conversion
patent, September 1999

Process of Casting Titanium and Related Metal and Alloys
patent, September 1957

Sublimation purifying method and apparatus
patent-application, February 2003

Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions
journal, April 2004