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Title: Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications

Abstract

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g., chemical and/or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc (e.g., at about 500-700° C. under reduced pressure) to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means (i.e., dissolution in acid, followed by ion exchange).

Inventors:
;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531870
Patent Number(s):
8526561
Application Number:
12/462,099
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
G - PHYSICS G21 - NUCLEAR PHYSICS G21K - TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR
DOE Contract Number:  
AC02-06CH11357; W-31-109-ENG-38
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009-07-29
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 07 ISOTOPE AND RADIATION SOURCES

Citation Formats

Ehst, David A., and Bowers, Delbert L. Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications. United States: N. p., 2013. Web.
Ehst, David A., & Bowers, Delbert L. Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications. United States.
Ehst, David A., and Bowers, Delbert L. Tue . "Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications". United States. https://www.osti.gov/servlets/purl/1531870.
@article{osti_1531870,
title = {Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications},
author = {Ehst, David A. and Bowers, Delbert L.},
abstractNote = {The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g., chemical and/or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc (e.g., at about 500-700° C. under reduced pressure) to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means (i.e., dissolution in acid, followed by ion exchange).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}

Works referenced in this record:

Production of radioisotopes with a high specific activity by isotopic conversion
patent, September 1999


Separation Metals
patent, December 1968


Production of no-carrier added 67Cu
journal, January 1986

  • Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36
  • https://doi.org/10.1016/0883-2889(86)90192-9

Production of radioisotopes with a high specific activity by isotopic conversion
patent, March 2001


The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970


The Preparation of High Specific Activity Copper 64
journal, January 1964


Electron Acceleration beyond 200 MeV in Underdense Plasmas using Table Top Laser Systems
conference, January 2002


Method of producing molybdenum-99
patent, July 1998


    Works referencing / citing this record:

    Production of copper-67 from an enriched zinc-68 target
    patent, June 2018