Lipid-peptide-polymer conjugates and nanoparticles thereof

Xu, Ting; Dong, He; Shu, Jessica

Lipid-peptide-polymer conjugates and nanoparticles thereof

Patent · Tue Jun 02 04:00:00 EDT 2015

OSTI ID:1183465

Xu, Ting; Dong, He; Shu, Jessica

The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,044,514

Application Number:: 13/610,637

OSTI ID:: 1183465

Country of Publication:: United States

Language:: English

References (7)

Water self-diffusion in nonionic surfactant solutions. Hydration and obstruction effects Nilsson, Per Gunnar; Lindman, Bjoern The Journal of Physical Chemistry, Vol. 87, Issue 23, p. 4756-4761 https://doi.org/10.1021/j100246a041	journal	November 1983
Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion Chen, Yee-Hsiung; Yang, Jen Tsi; Martinez, Hugo M. Biochemistry, Vol. 11, Issue 22, p. 4120-4131 https://doi.org/10.1021/bi00772a015	journal	October 1972
The crystal structure of the designed trimeric coiled coil coil-VaLd: Implications for engineering crystals and supramolecular assemblies Ogihara, Nancy L.; Weiss, Manfred S.; Eisenberg, David Protein Science, Vol. 6, Issue 1, p. 80-88 https://doi.org/10.1002/pro.5560060109	journal	January 1997
New Design of Helix Bundle Peptide−Polymer Conjugates Shu, Jessica Y.; Tan, Cen; DeGrado, William F. Biomacromolecules, Vol. 9, Issue 8, p. 2111-2117 https://doi.org/10.1021/bm800113g	journal	August 2008
Pharmaceutics and Drug Delivery Aspects of Heme and Porphyrin Therapy Cannon, John B. Journal of Pharmaceutical Sciences, Vol. 82, Issue 5, p. 435-446 https://doi.org/10.1002/jps.2600820502	journal	May 1993
Magainins as paradigm for the mode of action of pore forming polypeptides Matsuzaki, Katsumi Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, Vol. 1376, Issue 3, p. 391-400 https://doi.org/10.1016/S0304-4157(98)00014-8	journal	November 1998
Protein Folding: A Glimpse of the Holy Grail? Berendsen, H. J. C. Science, Vol. 282, Issue 5389, p. 642-643 https://doi.org/10.1126/science.282.5389.642	journal	October 1998

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