Title: Methods and compounds for chemical ligation

Abstract

Compositions and methods for chemical ligation are provided. Methods for nucleic acid sequencing, nucleic acid assembly and nucleic acid synthesis are also provided.

Inventors:

Church, George M.; Sismour, A. Michael

Issue Date:

Tue Jul 09 00:00:00 EDT 2013

Research Org.:

Harvard College (Cambridge, MA)

Sponsoring Org.:

USDOE

OSTI Identifier:

1087892

Patent Number(s):

8481258

Application Number:

12/628,518

Assignee:

President and Fellows of Harvard College (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C07H21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6813 - Hybridisation assays
C12Q2523/109 - chemical ligation between nucleic acids

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DOE Contract Number:  

FG02-02ER63445

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY