Global to push GA events into
skip to main content

Title: Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide

The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery system comprising: a) a calix[n]arene-crown-[m]-ether compound, wherein n is an integer greater than 3, and wherein m is an integer greater than 3, the calix[n]arene-crown-[m]-ether compound comprising at least two ionizable groups; and b) an antibody attached to the calix[n]arene-crown-[m]-ether compound. In another aspect, the invention includes a method of making a radium complexing compound, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising n phenolic hydroxyl groups; b) providing a crown ether precursor, the crown ether precursor comprising a pair of tosylated ends; c) reacting the pair of tosylated ends with a pair of the phenolic hydroxyl groups to convert said pair of phenolic hydroxyl groups to ether linkages, the ether linkages connecting the crown ether precursor to the calix[n]arene to form a calix[n]arene-crown-[m]-ether compound, wherein m is an integer greater than 3; d) converting remaining phenolic hydroxyl groups to esters; e) converting the esters to acids, the acids being proximate a crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound; and f) providing a Ra.sup.2+ ionmore » within the crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound.« less
Inventors:
 [1];  [2];  [2]
  1. (Richland, WA)
  2. (Moscow, ID)
Issue Date:
OSTI Identifier:
873235
Assignee:
Battelle Memorial Institute (Richland, WA); Idaho Research Foundation, Inc. (Moscow, ID) PNNL
Patent Number(s):
US 6117413
Contract Number:
AC06-76RL01830
Research Org:
BATTELLE MEMORIAL INSTITUTE
Country of Publication:
United States
Language:
English
Subject:
radionuclide-binding; compound; radionuclide; delivery; method; radium; complexing; extracting; delivering; pertains; compounds; specifically; bind; radionuclides; methods; aspect; comprising; calix; arene-crown-; -ether; integer; ionizable; antibody; attached; providing; arene; phenolic; hydroxyl; crown; precursor; pair; tosylated; reacting; convert; linkages; connecting; form; converting; remaining; esters; acids; proximate; crown-; portion; phenolic hydroxyl; compound comprising; specifically bind; antibody attach; /424/999/