Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making
Abstract
The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
- Inventors:
- Issue Date:
- Research Org.:
- US Department of Energy (USDOE), Washington, DC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1079245
- Patent Number(s):
- 8293780
- Application Number:
- 13/422,158
- Assignee:
- U.S. Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Gakh, Andrei A, Vovk, Mykhaylo V, Mel'nychenko, Nina V, and Sukach, Volodymyr A. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making. United States: N. p., 2012.
Web.
Gakh, Andrei A, Vovk, Mykhaylo V, Mel'nychenko, Nina V, & Sukach, Volodymyr A. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making. United States.
Gakh, Andrei A, Vovk, Mykhaylo V, Mel'nychenko, Nina V, and Sukach, Volodymyr A. Tue .
"Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making". United States. https://www.osti.gov/servlets/purl/1079245.
@article{osti_1079245,
title = {Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making},
author = {Gakh, Andrei A and Vovk, Mykhaylo V and Mel'nychenko, Nina V and Sukach, Volodymyr A},
abstractNote = {The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 23 00:00:00 EDT 2012},
month = {Tue Oct 23 00:00:00 EDT 2012}
}
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Works referenced in this record:
Bioisosterism: A Rational Approach in Drug Design
journal, January 1996
- Patani, George A.; LaVoie, Edmond J.
- Chemical Reviews, Vol. 96, Issue 8