skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making

Abstract

The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. ##STR00001## In particular, the invention relates N-substituted derivatives of 4-(hetero)aryl-1,2,5-oxadiazol-3-yl amines having the structural Formula (I) and (II), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. Meaning of R1 and R2 in the Formula (I) and (II) are defined in claim 1. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.

Inventors:
; ; ; ; ; ; ;
Issue Date:
Research Org.:
U.S. Department of Energy, Washington, DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1082680
Patent Number(s):
8,362,047
Application Number:
12/822,243
Assignee:
U.S. Department of Energy (Washington, DC)
DOE Contract Number:  
3548
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Jun 24
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Gakh, Andrei A., Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A., Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, and Sosnov, Andrey V. Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making. United States: N. p., 2013. Web.
Gakh, Andrei A., Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A., Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, & Sosnov, Andrey V. Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making. United States.
Gakh, Andrei A., Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A., Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, and Sosnov, Andrey V. Tue . "Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making". United States. https://www.osti.gov/servlets/purl/1082680.
@article{osti_1082680,
title = {Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making},
author = {Gakh, Andrei A. and Krasavin, Mikhail and Karapetian, Ruben and Rufanov, Konstantin A. and Konstantinov, Igor and Godovykh, Elena and Soldatkina, Olga and Sosnov, Andrey V.},
abstractNote = {The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. ##STR00001## In particular, the invention relates N-substituted derivatives of 4-(hetero)aryl-1,2,5-oxadiazol-3-yl amines having the structural Formula (I) and (II), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. Meaning of R1 and R2 in the Formula (I) and (II) are defined in claim 1. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

High-Throughput Screening--Based Identification of Paramyxovirus Inhibitors
journal, July 2008