Molecular predictors of therapeutic response to specific anti-cancer agents
Abstract
Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1333733
- Patent Number(s):
- 9506926
- Application Number:
- 13/401,780
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Feb 21
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Spellman, Paul T., Gray, Joe W., Sadanandam, Anguraj, Heiser, Laura M., Gibb, William J., Kuo, Wen-lin, and Wang, Nicholas J. Molecular predictors of therapeutic response to specific anti-cancer agents. United States: N. p., 2016.
Web.
Spellman, Paul T., Gray, Joe W., Sadanandam, Anguraj, Heiser, Laura M., Gibb, William J., Kuo, Wen-lin, & Wang, Nicholas J. Molecular predictors of therapeutic response to specific anti-cancer agents. United States.
Spellman, Paul T., Gray, Joe W., Sadanandam, Anguraj, Heiser, Laura M., Gibb, William J., Kuo, Wen-lin, and Wang, Nicholas J. Tue .
"Molecular predictors of therapeutic response to specific anti-cancer agents". United States. https://www.osti.gov/servlets/purl/1333733.
@article{osti_1333733,
title = {Molecular predictors of therapeutic response to specific anti-cancer agents},
author = {Spellman, Paul T. and Gray, Joe W. and Sadanandam, Anguraj and Heiser, Laura M. and Gibb, William J. and Kuo, Wen-lin and Wang, Nicholas J.},
abstractNote = {Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 29 00:00:00 EST 2016},
month = {Tue Nov 29 00:00:00 EST 2016}
}
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