Investigation of the complexation between quinidine carbamate and the enantiomers of 3-chloro-1-phenyl-propanol by circular dichroism and UV spectroscopy

Journal Article · Sat Apr 01 00:00:00 EST 2006 · Journal of Liquid Chromatography & Related Technologies

DOI:https://doi.org/10.1080/10826070600674752· OSTI ID:989613

Guiochon, Georges A ^[1]; Asnin, Leonid ^[2]

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1. ORNL
2. University of Tennessee, Knoxville (UTK)

UV and circular dichroism spectroscopic measurements showed that the molecular interactions in hexane/ethyl-acetate solutions between dihydroquinidine tert-butylcarbamate, used as a model for the quinidine carbamate chiral selector (QD), and 3-chloro-1-phenyl-propanol are too weak to affect the corresponding spectra of these compounds. The weak interactions between QD and 3-chloro-1-phenyl-propanol are probably masked by the formation of self-associated dimeric structures in solution.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: DE-AC05-00OR22725
• OSTI ID: 989613
• Journal Information: Journal of Liquid Chromatography & Related Technologies, Vol. 29, Issue 10; ISSN 1082-6076
• Country of Publication: United States
• Language: English

Related Subjects

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
CARBAMATES
DICHROISM
SPECTRA
SPECTROSCOPY
WEAK INTERACTIONS
chiral selector
enantiorecognition
Job's method
mole-ratio method