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Title: Nucleic acid detection compositions

Abstract

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Inventors:
 [1];  [1];  [1];  [1];  [1]
  1. Madison, WI
Publication Date:
Research Org.:
Third Wave Technologies, Inc. (Madison, WI)
Sponsoring Org.:
USDOE
OSTI Identifier:
985508
Patent Number(s):
7,407,782
Application Number:
; TRN: US201016%%2030
Assignee:
Third Wave Technologies, Inc. (Madison, WI) CHO
DOE Contract Number:
FG02-94ER81891
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CLEAVAGE; DETECTION; ENZYMES; INVENTIONS; NUCLEASES; NUCLEIC ACIDS; TARGETS

Citation Formats

Prudent, James R, Hall, Jeff G, Lyamichev, Victor I, Brow, Mary Ann, and Dahlberg, James L. Nucleic acid detection compositions. United States: N. p., 2008. Web.
Prudent, James R, Hall, Jeff G, Lyamichev, Victor I, Brow, Mary Ann, & Dahlberg, James L. Nucleic acid detection compositions. United States.
Prudent, James R, Hall, Jeff G, Lyamichev, Victor I, Brow, Mary Ann, and Dahlberg, James L. Tue . "Nucleic acid detection compositions". United States. doi:. https://www.osti.gov/servlets/purl/985508.
@article{osti_985508,
title = {Nucleic acid detection compositions},
author = {Prudent, James R and Hall, Jeff G and Lyamichev, Victor I and Brow, Mary Ann and Dahlberg, James L},
abstractNote = {The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 05 00:00:00 EDT 2008},
month = {Tue Aug 05 00:00:00 EDT 2008}
}

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