Conserved protein YecM from Escherichia coli shows structural homology to metal-binding isomerases and oxygenases.
The crystal structure of protein YecM{sup 1} has been determined at 1.6 {angstrom} resolution as a part of the ongoing structural genomics initiative (http://www.mcsg.anl.gov). The YecM is a conserved, hypothetical Escherichia coli protein with sequence homologs found exclusively in bacteria, including Salmonella typhimunium, Yersinia pestis, Vibrio cholerae, Haemophilus influenza, and Pasteurella multocida. YecM (188 residues) shows also sequence similarity to proteins in COG database (http://www.ncbi.nlm.nih.gov/cgi-bin/COG/palox-?COG3102). YecM (Pfam-B domain 24546) was selected as a structural genomics target it shows no sequence similarity with proteins of known three-dimensional structure and therefore, may contain a previously unobserved field.
- Research Organization:
- Argonne National Laboratory (ANL)
- Sponsoring Organization:
- NIH; SC
- DOE Contract Number:
- AC02-06CH11357
- OSTI ID:
- 961106
- Report Number(s):
- ANL/BIO/JA-44663
- Journal Information:
- Proteins: Struct. Function Genet., Journal Name: Proteins: Struct. Function Genet. Journal Issue: 2003 Vol. 51
- Country of Publication:
- United States
- Language:
- ENGLISH
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