Relative biological effectiveness of proton medical beam at Moscow synchrotron determined by the Chinese hamster cells assay
Journal Article
·
· International Journal of Radiation Oncology, Biology and Physics
- Institute of Biophysics, Moscow (Russian Federation); and others
Assessment of relative biological effectiveness (RBE) of the proton medical beam at Moscow synchrotron. The study was performed at Moscow proton medical facility (Institute for Theoretical and Experimental Physics). Relative biological effectiveness of the synchrotron proton beam was assessed at the entry of the unmodulated 179 MeV beam and in the center of spread out Bragg peak (SOBP), from measurements of the survival of Chinese hamster cells (clone 431). Gamma-radiation of {sup 60}Co was used as a reference source. According to the linear regression model, mean RBE values at 37% survival level were found to be 1.10 {+-} 0.04 at the beam entry and 1.14 {+-} 0.05 in the center of SOBP. Values of RBE obtained using the linear-quadratic model for 10% and 37% survival levels were 1.09 and 1.07, respectively, at the beam entry and 1.07 and 1.08, respectively, in the center of SOBP. The data obtained indicated that (a) the RBE values at the entry of the unmodulated beam and at the center of the SOBP are in close agreement, with an average of about 1.10; (b) protons are radiobiologically somewhat more effective than {sup 60}Co gamma rays; and (c) high pulse dose rate of the medical beam does not significantly affect biological effects of the beam. 18 refs., 3 figs., 2 tabs.
- OSTI ID:
- 96102
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 31; ISSN IOBPD3; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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