Relative biological effectiveness of a high energy modulated proton beam using a spontaneous murine tumor in vivo. [Protons, /sup 60/Co]

Conference · Mon Sep 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6784034

Urano, M ^[1]; Goitein, M; Verhey, L; Mendiondo, O; Suit, H D; Koehler, A

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1. Harvard Medical School, Boston, MA

The relative biological effectiveness (RBE) for proton beams produced by 160 MeV Harvard University synchrocyclotron was studied in C3Hf/Sed mouse fibrosarcoma (FSa-II). Reference radiation was Cobalt-60 ..gamma..-ray. Cell survival was determined by 2 types of lung colony assays. Tumors were irradiated with 1 to 10 doses in the center of spread-out Bragg peak (SOBP) or in an incident plateau area. Survival curves were analyzed by alpha-beta (linear quadratic) model and RBE was determined at various survival levels. The RBEs at survival levels of 0.5, 0.1, and 0.01 were 1.16 +- 0.12, 1.16 +- 0.06 and 1.17 +- 0.05 respectively. The RBE in the incident plateau was not significantly different from that in SOBP.

• OSTI ID: 6784034
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:9
• Country of Publication: United States
• Language: English

Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ANIMALS
ANOXIA
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BRAGG CURVE
CELL KILLING
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
COMPARATIVE EVALUATIONS
CYCLIC ACCELERATORS
DATA
DIAGRAMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ENERGY RANGE
ENERGY TRANSFER
EXPERIMENTAL DATA
FIBROSARCOMAS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HARVARD SYNCHROCYCLOTRON
IN VIVO
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LET
MAMMALS
MEV RANGE
MEV RANGE 100-1000
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUCLEON BEAMS
NUMERICAL DATA
ODD-ODD NUCLEI
PARTICLE BEAMS
PROTON BEAMS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
RODENTS
SARCOMAS
SURVIVAL CURVES
SYNCHROCYCLOTRONS
TIME DEPENDENCE
VERTEBRATES
YEARS LIVING RADIOISOTOPES