Looking for Darwin's footprints in the microbial world

Journal Article · Mon Mar 30 04:00:00 EDT 2009 · Trends in Microbiology

DOI:https://doi.org/10.1016/j.tim.2009.02.002· OSTI ID:957407

Shapiro, B Jesse; David, Lawrence A; Friedman, Jonathan; Alm, Eric J

As we observe the 200th anniversary of Charles Darwin's birthday, microbiologists interested in the application of Darwin's ideas to the microscopic world have a lot to celebrate: an emerging picture of the (mostly microbial) Tree of Life at ever-increasing resolution, an understanding of horizontal gene transfer as a driving force in the evolution of microbes, and thousands of complete genome sequences to help formulate and refine our theories. At the same time, quantitative models of the microevolutionary processes shaping microbial populations remain just out of reach, a point that is perhaps most dramatically illustrated by the lack of consensus on how (or even whether) to define bacterial species. We summarize progress and prospects in bacterial population genetics, with an emphasis on detecting the footprint of positive Darwinian selection in microbial genomes.

• Research Organization: Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
• Sponsoring Organization: Physical Biosciences Division
• DOE Contract Number: AC02-05CH11231
• OSTI ID: 957407
• Report Number(s): LBNL-1886E
• Journal Information: Trends in Microbiology, Journal Name: Trends in Microbiology
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENES
GENETICS
RESOLUTION
microevolutionary
microbial populations
bacterial population genetics