Reversible PH Lability of Cross-Linked Vault Nanocapsules

Journal Article · Thu May 28 00:00:00 EDT 2009 · Nano Lett. 8:3510,2008

OSTI ID:953519

Yu, M; Ng, B C; Rome, L H; Tolbert, S H; Monbouquette, H G

Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10 000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.

• Research Organization: SLAC National Accelerator Lab., Menlo Park, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-76SF00515
• OSTI ID: 953519
• Report Number(s): SLAC-REPRINT-2009-364; TRN: US201002%%1347
• Journal Information: Nano Lett. 8:3510,2008, Vol. 8, Issue 10
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
CROSS-LINKING
DELIVERY
DIMENSIONS
DRUGS
HUMAN POPULATIONS
POTENTIALS
PROTEINS
RANGE
REAGENTS
VEHICLES
Other
OTHER