Characterization of Highly Nonlinear and Anisotropic Vascular Tissues from Experimental Inflation Data: a Validation Study Towards the Use of Clinical Data for In-vivo Modeling and Analysis
A new ¯nite element (FE) modeling approach is proposed to model blood vessel by using data from blood vessel during in°ation instead of using data from biaxial test to estimate the tissue property. A particular constitutive equation is used to model the tissue property as a dispersed transverse isotropic hyperelastic material under both single-layer and multi-layer assumption for comparison. In order to compensate the drawback of using this type of data that does not provide su±cient information to estimate the tissue property in axial direction, the axial/circumferential elastic moduli ratio is being constrained in a typical range. The semi-global inverse method is applied with the pressure-diameter test data from porcine thoracic aorta to esti- mate the optimal tissue property. The simulated data of all cases is then compared with the biaxial test data. It is found that the single-layer model without the con- straint ¯ts well with the pressure-diameter test data but not with the biaxial test data at the axial direction, so it is suitable only for pressure-diameter analysis. The multi-layer model with the constraint ¯ts well with the pressure-diameter data and also the biaxial test data, so it is suitable to estimate the tissue property and for stress-strain analysis. The constitutive equation and the semi-global inverse method are found e±cient in this study. We believe that this new approach that uses this type of data, such as magnetic resonance imaging (MRI) data that could be ob- tained non-invasive in vivo, is time-e±cient and would be bene¯cial for pre-surgical analysis.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 946358
- Report Number(s):
- PNNL-SA-52382; ABMECF; TRN: US200903%%388
- Journal Information:
- Annals of Biomedical Engineering, 36(10):1668-1680, Vol. 36, Issue 10; ISSN 0090-6964
- Country of Publication:
- United States
- Language:
- English
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