R. Bruce Merrifield and Solid-Phase Peptide Synthesis: A Historical Assessment
Journal Article
·
· Biopolymers:Peptide Science, vol. 90, no. 3, January 22, 2008, pp. 175 -184
OSTI ID:944322
Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 944322
- Report Number(s):
- UCRL-JRNL-237037
- Journal Information:
- Biopolymers:Peptide Science, vol. 90, no. 3, January 22, 2008, pp. 175 -184, Journal Name: Biopolymers:Peptide Science, vol. 90, no. 3, January 22, 2008, pp. 175 -184 Journal Issue: 3 Vol. 90
- Country of Publication:
- United States
- Language:
- English
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