Dosage-Dependent Proteome Response of Shewanella oneidensis MR-1 to Acute Chromate Challenge
Journal Article
·
· Journal of Proteome Research
- ORNL
Proteome alterations in the metal-reducing bacterium Shewanella oneidensis MR-1 in response to different acute dose challenges (0.3, 0.5, or 1 mM) of the toxic metal chromate [Cr(VI)] were characterized with multidimensional HPLC-MS/MS on a linear trapping quadrupole MS. A total of 2,406 functionally diverse proteins were identified, with a subset demonstrating dosage-dependent up- and down-regulated expression, such as proteins involved in detoxification and iron binding and transport.
- Research Organization:
- Oak Ridge National Laboratory (ORNL)
- Sponsoring Organization:
- SC USDOE - Office of Science (SC)
- DOE Contract Number:
- AC05-00OR22725
- OSTI ID:
- 931468
- Journal Information:
- Journal of Proteome Research, Journal Name: Journal of Proteome Research Journal Issue: 5 Vol. 6
- Country of Publication:
- United States
- Language:
- English
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