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Title: Nanosensors based on functionalized nanoparticles and surface enhanced raman scattering

Abstract

Surface-Enhanced Raman Spectroscopy (SERS) is a vibrational spectroscopic technique that utilizes metal surfaces to provide enhanced signals of several orders of magnitude. When molecules of interest are attached to designed metal nanoparticles, a SERS signal is attainable with single molecule detection limits. This provides an ultrasensitive means of detecting the presence of molecules. By using selective chemistries, metal nanoparticles can be functionalized to provide a unique signal upon analyte binding. Moreover, by using measurement techniques, such as, ratiometric received SERS spectra, such metal nanoparticles can be used to monitor dynamic processes in addition to static binding events. Accordingly, such nanoparticles can be used as nanosensors for a wide range of chemicals in fluid, gaseous and solid form, environmental sensors for pH, ion concentration, temperature, etc., and biological sensors for proteins, DNA, RNA, etc.

Inventors:
 [1];  [2];  [1];  [3];  [1];  [2]
  1. Brentwood, CA
  2. Livermore, CA
  3. Oakland, CA
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
920688
Patent Number(s):
7,301,624
Application Number:
10/935,783
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Talley, Chad E, Huser, Thomas R, Hollars, Christopher W, Lane, Stephen M, Satcher, Jr., Joe H., Hart, Bradley R, and Laurence, Ted A. Nanosensors based on functionalized nanoparticles and surface enhanced raman scattering. United States: N. p., 2007. Web.
Talley, Chad E, Huser, Thomas R, Hollars, Christopher W, Lane, Stephen M, Satcher, Jr., Joe H., Hart, Bradley R, & Laurence, Ted A. Nanosensors based on functionalized nanoparticles and surface enhanced raman scattering. United States.
Talley, Chad E, Huser, Thomas R, Hollars, Christopher W, Lane, Stephen M, Satcher, Jr., Joe H., Hart, Bradley R, and Laurence, Ted A. 2007. "Nanosensors based on functionalized nanoparticles and surface enhanced raman scattering". United States. https://www.osti.gov/servlets/purl/920688.
@article{osti_920688,
title = {Nanosensors based on functionalized nanoparticles and surface enhanced raman scattering},
author = {Talley, Chad E and Huser, Thomas R and Hollars, Christopher W and Lane, Stephen M and Satcher, Jr., Joe H. and Hart, Bradley R and Laurence, Ted A},
abstractNote = {Surface-Enhanced Raman Spectroscopy (SERS) is a vibrational spectroscopic technique that utilizes metal surfaces to provide enhanced signals of several orders of magnitude. When molecules of interest are attached to designed metal nanoparticles, a SERS signal is attainable with single molecule detection limits. This provides an ultrasensitive means of detecting the presence of molecules. By using selective chemistries, metal nanoparticles can be functionalized to provide a unique signal upon analyte binding. Moreover, by using measurement techniques, such as, ratiometric received SERS spectra, such metal nanoparticles can be used to monitor dynamic processes in addition to static binding events. Accordingly, such nanoparticles can be used as nanosensors for a wide range of chemicals in fluid, gaseous and solid form, environmental sensors for pH, ion concentration, temperature, etc., and biological sensors for proteins, DNA, RNA, etc.},
doi = {},
url = {https://www.osti.gov/biblio/920688}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {11}
}