Energetics and Dynamics of Peptide Fragmentation from Multiple-Collision Activation and Surface-Induced Dissociation Studies

Journal Article · Thu Jun 10 04:00:00 EDT 2004 · European Journal of Mass Spectrometry, 10(2):259-267

DOI:https://doi.org/10.1255/ejms.641· OSTI ID:919313

Laskin, Julia

This account summarizes the energetics and dynamics of peptide fragmentation obtained using a new approach recently developed in our laboratory. The approach involves RRKM modeling of time- and energy-resolved MS/MS data obtained using collisional activation. We demonstrate that surface-induced dissociation (SID) on a long timescale of Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) is perfectly suited for studying the energetics and dynamics of peptide fragmentation.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 919313
• Report Number(s): PNNL-SA-39375; 14395; KC0302020
• Journal Information: European Journal of Mass Spectrometry, 10(2):259-267, Journal Name: European Journal of Mass Spectrometry, 10(2):259-267
• Country of Publication: United States
• Language: English

Related Subjects

Environmental Molecular Sciences Laboratory
FT-ICR mass spectrometry
RRKM/QET
SORI-CID
dissociation energy
energy partitioning
entropic factor
fragmentation energetics and dynamics
kinetic shift
peptide ions
surface-induced dissociation (SID)