Initial report of a genome search for the affective disorder predisposition gene in the Old Order Amish pedigrees: Chromosomes 1 and 11

Journal Article · Thu Dec 15 04:00:00 EST 1994 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320540421· OSTI ID:91115

Gerhard, D S; Bland, S D ^[1]; LaBuda, M C ^[2]

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1. Washington Univ. School of Medicine, St. Louis, MO (United States)
2. NIDA Addiction Research Center, Baltimore, MD (United States); and others

Family data have suggested that some forms of major affective disorder are genetic. Certain of the Old Order Amish pedigrees have a familial form of the disease. In this report we present the results of genetic analyses under autosomal dominant mode of transmission with reduce penetrance and three different disease hierarchies. The pedigrees were genotyped with 28 markers from chromosome 1 and 23 markers from chromosomes 11. None of the markers result in a significantly positive lod score. 49 refs., 1 fig., 4 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 91115
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 54; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
COMMUNITIES
DOMINANT MUTATIONS
GENES
GENETIC MAPPING
GENETICS
GENOTYPE
HEREDITARY DISEASES
HUMAN CHROMOSOME 1
HUMAN CHROMOSOMES
MENTAL DISORDERS
POLYMERASE CHAIN REACTION
STATISTICS